PMID: 9421854Jan 9, 1998Paper

Inhibition of nitric oxide synthesis during severe shock but not after resuscitation increases hepatic injury and neutrophil accumulation in hemorrhaged rats

Shock
B HarbrechtA B Peitzman

Abstract

Hemorrhagic shock results in hepatocellular dysfunction and hepatic injury that may contribute to the development of liver failure and multiple organ dysfunction in trauma patients. The specific mediators involved in this process remain incompletely defined. We have previously demonstrated that inhibition of nitric oxide (NO) synthesis in a rat model of moderately severe hemorrhagic shock increases hepatic injury, suggesting that NO synthesis is beneficial after hemorrhage. To further define the role of NO in hepatic function during hemorrhagic shock, rats were subjected to a severe hemorrhagic shock insult in which they were bled to a mean arterial pressure of 40 mmHg until 40% of their shed blood had been returned and then were resuscitated. Rats were treated with the NO synthase inhibitor L-nitroarginine methyl ester (L-NAME) or the NO donor S-nitroso-N-acetylpenicillamine beginning either during the hypotensive period or after resuscitation. When instituted during the hypotensive period, low dose L-NAME infusion significantly increased hepatic injury. When L-NAME was infused after resuscitation, no increase in hepatic injury was detected even when the L-NAME dose was increased by a factor of four. The increased hepatic inju...Continue Reading

Citations

Oct 12, 2000·Biochemical and Biophysical Research Communications·D A GellerK Hatakeyama
Dec 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rahul S KotiAlexander M Seifalian
Sep 29, 2000·Critical Care Medicine·M K AngeleI H Chaudry
Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Florian LoeheMartin Kurt Angele
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G Clemens
Jun 17, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Martijn PoezeNicolaas E P Deutz
Dec 2, 2008·The Journal of Surgical Research·Niteen TapuriaBrian R Davidson
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takashi KaizuDavid A Geller
Aug 10, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Min-Sun KimSung-Joo Park
Dec 22, 1999·The Journal of Surgical Research·F M AkgürM F Brown
Dec 18, 2013·PloS One·Isabella WernerAndres Beiras-Fernandez
Aug 9, 2001·The Journal of Trauma·G Martinez-MierP A Ward
Nov 21, 2015·Hepatitis Monthly·Hassan SoleimanpourSeyed Moayed Alavian
May 1, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Eduardo E Montalvo-JaveDavid A Geller
Oct 26, 2005·Shock·Michael T HandriganRobert A Bowden
Sep 19, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rahul S KotiBrian R Davidson

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