PMID: 15353073Sep 9, 2004Paper

Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum

Reproductive Biomedicine Online
S PreutthipanA M Dharmarajan

Abstract

To determine if nitric oxide (NO) plays a role in corpus luteum (CL) physiology by affecting progesterone secretion or luteal apoptosis, an in-vitro pseudopregnant rabbit ovarian perfusion system was used to measure the effects of an inhibitor of NO synthesis, NG-nitro-L-arginine methyl ester (L-NAME), on progesterone secretion and corpus luteal apoptosis as measured by internucleosomal DNA breakdown. Pseudopregnant rabbit ovaries perfused in vitro with L-NAME did not demonstrate any significant differences compared with control ovaries in progesterone secretion. However, apoptosis, as measured by internucleosomal breakdown, was significantly increased in L-NAME-perfused CL compared with controls. While NO does not appear to directly affect progesterone secretion, there does appear to be a role for NO in CL maintenance, or a role for inhibition of NO production in CL regression.

References

May 1, 1988·Journal of Reproduction and Fertility·W SchlegelH M Beier
Nov 1, 1983·Journal of Reproduction and Fertility·R A Nowak, J M Bahr
Oct 1, 1995·The Journal of Endocrinology·H M FraserP J Illingworth
Nov 1, 1993·Human Reproduction·W WuttkeS Spiess
Apr 1, 1993·Endocrine Reviews·R A Schwartzman, J A Cidlowski

❮ Previous
Next ❯

Citations

Jan 18, 2006·Reproductive Biomedicine Online·Ashok AgarwalRakesh Sharma
Feb 24, 2006·The Journal of Reproduction and Development·Anna J KorzekwaDariusz J Skarzynski
Aug 24, 2013·Reproduction in Domestic Animals = Zuchthygiene·D J SkarzynskiR Meidan
Jul 6, 2010·The International Journal of Biochemistry & Cell Biology·Kaïs H Al-GuboryCatherine Garrel
Nov 18, 2017·Oxidative Medicine and Cellular Longevity·Shan WangXinghui Liu
Jul 26, 2019·Oxidative Medicine and Cellular Longevity·Sara MendesElisabete Silva
Aug 22, 2018·Reproductive Biology and Endocrinology : RB&E·Jiayin LuYulan Dong
Jan 29, 2021·Animals : an Open Access Journal From MDPI·Massimo ZeraniMargherita Maranesi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis