Inhibition of NMDA-induced increase in brain temperature by N-omega-nitro-L-arginine and indomethacin in rats

Brain Research
S HaraT Endo

Abstract

Intracerebroventricular administration of N-methyl-D-aspartate (NMDA) caused an increase in brain temperature, which appeared rapidly and preceded that in rectal temperature, in urethane-anesthetized rats. The increase in brain temperature was divided into two phases, an early increase and a late increase. Intracerebroventricular indomethacin, a cyclooxygenase inhibitor, completely abolished the NMDA-induced late increase, but not the early increase, in brain temperature. On the other hand, intracerebroventricular N-omega-nitro-L-arginine, a potent inhibitor of nitric oxide synthase, strongly suppressed both the early and the late increases. These findings suggest that both nitric oxide and prostaglandins may be involved in the increase in brain temperature after NMDA receptor activation.

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Citations

Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·S M AllanN J Rothwell
Mar 28, 2001·Annals of the New York Academy of Sciences·S M Allan
Nov 11, 2003·Canadian Journal of Physiology and Pharmacology·F CaniniJ Bittel
Aug 31, 2001·European Journal of Pharmacology·F CaniniL Bourdon

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