Inhibition of nNOS and COX-2 expression by lutein in acute retinal ischemia

Nutrition
Jun-Sub ChoiChoun-Ki Joo

Abstract

Lutein is a major nutrient in the retina. Lutein has an antioxidative effect and protects against macular degeneration and retinal degenerative disease. However, the mechanism of lutein is not clear in retinal degeneration, and a role for lutein is not known in ischemic injury. In this study, an ischemia-induced rat retina was examined to determine the effect of the lutein on ischemic retinal cell death. We used a transient ischemia model of high intraocular pressure in the rat. Lutein (Kemin Foods, LC) was injected into the intraperitoneal or intravitreous before ischemia. Retinal degeneration was observed by light microscopy 24 h after ischemia. Expressions of neuronal nitric oxide synthase (nNOS) and cyclo-oxygenase-2 (COX-2) were detected by western blot analysis at various times after retinal ischemia. The nNOS and COX-2 expression levels were increased early in ischemic control retinas, but these increases were inhibited by lutein. In addition, the inhibitory effect of lutein was observed to be dose dependent. Further, ischemia-induced cell death was inhibited by lutein. Lutein-injected ischemic retina appeared similar to normal retina. This study investigated the protective effect of lutein on retinal ischemia and the in...Continue Reading

References

Sep 1, 1996·Vision Research·I M GoldsteinS Roth
Jul 1, 1997·Experimental Eye Research·J T LandrumK E Sprague
Sep 1, 1997·Diabetes·W Stahl, H Sies
Jun 18, 1998·Annals of Neurology·T SairanenP J Lindsberg
Sep 24, 1998·Current Eye Research·C ChanM O Tso
Nov 5, 1999·Archives of Biochemistry and Biophysics·A SujakW I Gruszecki
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·C IadecolaM E Ross
Jul 5, 2001·Archives of Biochemistry and Biophysics·A JunghansW Stahl
Jun 20, 2002·Free Radical Research·M Cristina PolidoriPatrizia Mecocci
Mar 11, 2003·Annual Review of Nutrition·Norman I KrinskyRichard A Bone
Aug 2, 2003·Annals of Neurology·Sylvain DoréKatrin Andreasson
Dec 23, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tsutomu SasakiMasatsugu Hori
Feb 10, 2004·Progress in Retinal and Eye Research·Neville N OsborneJosé Melena
Apr 8, 2004·Toxicology Letters·Alexandra Alves-Rodrigues, Andrew Shao
Jul 21, 2004·Cell Calcium·M A MoroI Lizasoain

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Citations

Jun 18, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anat FleischmanOrna Geyer
Jul 16, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·L P RubinD H Adamkin
Nov 21, 2008·Nutrition Reviews·Billy R Hammond
Feb 8, 2011·Progress in Retinal and Eye Research·Eric L Lien, Billy R Hammond
Mar 7, 2020·Journal of Oral Science·Mamoru Takeda, Yoshihito Shimazu
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jose-Andres C PortilloCarlos S Subauste
Nov 11, 2015·Foods·James M Stringham, Nicole T Stringham
Mar 7, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jose-Andres C PortilloCarlos S Subauste
Feb 21, 2019·Pharmacology, Biochemistry, and Behavior·Ana Lúcia Bertarello ZeniAna Paula Dalmagro
Jul 3, 2021·Nutrients·Drake W LemPinakin Gunvant Davey
Aug 8, 2021·International Journal of Molecular Sciences·Stefania VernazzaAnna Maria Bassi

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