Dec 1, 1973

Inhibition of noradrenaline release by lysergic acid diethylamide

British Journal of Pharmacology
J Hughes


Lysergic acid diethylamide (LSD) inhibits the release of labelled noradrenaline from the guinea-pig vas deferens during intramural nerve stimulation and causes a corresponding reduction in the contractions of the smooth muscle. These effects of LSD are most prominent at low stimulus frequencies and they are prevented by treatment with phentolamine. It is concluded that LSD inhibits noradrenaline release by interacting with presynaptic alpha-adrenoceptors.

  • References9
  • Citations16


  • References9
  • Citations16


Mentioned in this Paper

Presynaptic Terminals
LSD Reaction
Smooth Muscle
Lysergic Acid Diethylamide
Norepinephrine, (+, -)-Isomer
Neurostimulation Procedure

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