Inhibition of normal human granulopoiesis in vitro by non-B non-T lymphocytes

British Journal of Haematology
T C MorrisP Hersey

Abstract

Normal non-adherent mononuclear cells were shown to inhibit colony formation by normal human marrow cells cultured for 7 d in semi-solid agar. Inhibition was the same using cells from the marrow donor or from an unrelated normal subject, and was shown to be dose-dependent over the range of 4 X 10(5) to 6 X 10(3) mononuclear cells per 1 X 10(5) marrow cells plated. Inhibition was not seen in 14 d cultures, and it is postulated that colony-forming cells sensitive to lymphocyte inhibition belonged to the population known to give rise to colonies after 7 d in culture. Cell fractionation studies showed that inhibition was due to non-B non-T lymphocytes, purified B cells or T cells being neither inhibitory nor stimulatory. Inhibition was only shown with intact viable lymphocytes and it was not possible to extract inhibitory activity from the cells, or to produce inhibition by media conditioned by lymphocytes. The effect was apparently due to a direct action on colony-forming cells in the marrow and was not due to inhibition of colony stimulating activity (CSA) production, or to absorption or inactivation of CSA. These results emphasize the need to include appropriate controls when looking for possible cell-mediated inhibitors in dise...Continue Reading

References

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Citations

Feb 1, 1984·Blut·T C MorrisJ P Isbister
Apr 1, 1982·British Journal of Haematology·T C Morris, P C Vincent
Mar 1, 1986·British Journal of Haematology·A E IrvineJ M Bridges
Jan 1, 1989·Clinical and Laboratory Haematology·T C MorrisJ P Isbister
Jul 1, 1993·British Journal of Haematology·F M CicuttiniA W Boyd
Jan 1, 1980·La Ricerca in Clinica E in Laboratorio·J C RenversezC M Barioz
Aug 1, 1980·Springer Seminars in Immunopathology·J SprentK Molnar-Kimber
Jun 1, 1982·American Journal of Hematology·R D Barr, C A Stevens
Jul 21, 2010·Journal of Leukocyte Biology·Lisa J A CrawfordAlexandra E Irvine
Nov 1, 1985·Scandinavian Journal of Haematology·T OlofssonE Persson
Jan 1, 1987·Critical Reviews in Oncology/hematology·G TrinchieriB Perussia

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