Inhibition of NOS2 ameliorates cardiac remodeling, improves heart function after myocardial infarction in rats

Basic Research in Cardiology
Bin ZhengYu-Hua Liao

Abstract

Previous studies have shown increased expression of nitric oxide synthase 2 (NOS2) in rat heart several weeks after myocardial infarction (MI). The aim of this study was to examine the effect of chronic administration of S-methylisothiourea (SMT), a selective NOS2 inhibitor, commenced one week after MI on hemodynamic parameters and left ventricular (LV) remodeling in rats. Rats with MI induced by left coronary ligation were given SMT (0.5 mg/kg/d) or saline by gavage starting one week after MI. After chronic administration for five weeks, hemodynamic and cardiac morphologic studies were performed, and lung water content, plasma NO(x) concentration, NOS2 protein level, myocyte size and collagen volume fraction of noninfarct LV area were quantified. The NO(x) concentration in plasma and the NOS2 protein level in noninfarct myocardium in MI rats were higher than controls. When compared with the MI rats receiving saline, chronic administration of SMT reduced myocyte size (15.1 +/- 1.6 microm vs 16.9 +/- 2.3 microm, P < 0.05), collagen volume fraction of noninfarct LV area (4.4% +/- 1.1% vs 5.7% +/- 1.2%, P < 0.01) and lung water content (77.4% +/- 1.4% vs 79.3% +/- 0.9%, P < 0.01), without affecting infarct size. Administration of ...Continue Reading

Citations

Aug 27, 2009·The Journal of Biological Chemistry·Shimin DongChunxiang Zhang
May 22, 2007·Antioxidants & Redox Signaling·Corinne BerthonnecheFrançois Boucher
Aug 2, 2013·Biological & Pharmaceutical Bulletin·Hiroyuki NishikawaAtsufumi Kawabata
Aug 31, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R L G FlumignanP J F Tucci

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