Inhibition of nuclear factor-κB signal by pyrrolidine dithiocarbamate alleviates lipopolysaccharide-induced acute lung injury

Oncotarget
Hongfu YangLei Yu

Abstract

This study mainly studied the effect of inhibition of nuclear factor-κB (NF-κB) signal by pyrrolidine dithiocarbamate (PDTC) on lipopolysaccharide (LPS)-induced inflammatory response, oxidative stress, and mitochondrial dysfunction in a murine acute lung injury model. The results showed that LPS exposure activated NF-κB and its upstream proteins and caused lung inflammation, oxidative stress, and mitochondrial dysfunction in mice. While inhibition of NF-κB by PDTC adminstration alleviated LPS-induced generation of lymphocytes, IL-1β, and TNF-α. Malondialdehyde, a common oxidative product, was markedly reduced after PDTC treatment in LPS-challenged mice. Furthermore, PDTC alleviated LPS-induced mitochondrial dysfunction via improving ATP synthesis and uncoupling protein 2 expression. In conclusion, inhibition of NF-κB by PDTC alleviated LPS-induced acute lung injury via maintaining inflammatory status, oxidative balance, and mitochondrial function in mice.

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Citations

Dec 11, 2019·Stress : the International Journal on the Biology of Stress·Yuxin Zheng, Zhiyi Zuo
Mar 14, 2019·Toxicology and Industrial Health·Runan QinYonghui Wu
Dec 21, 2019·Indian Journal of Ophthalmology·Lalitha Prajna
May 6, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sophia L AmbrusoSarah Faubel
May 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Devendra Kumar, Neerja Trivedi
Jun 3, 2021·Biomedicines·Myeounghoon ChaBae Hwan Lee

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Methods Mentioned

BETA
ELISA
MDA
bronchoalveolar
lavage
PCR
protein assay
electrophoresis

Software Mentioned

Primer
image J

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