PMID: 9545547Apr 18, 1998Paper

Inhibition of nuclear factor kappa B attenuates proinflammatory cytokine and inducible nitric-oxide synthase expression in postischemic myocardium

Biochimica Et Biophysica Acta
B ChandrasekarG L Freeman

Abstract

We have previously reported that induction of nuclear factor-kappa B (NF-kappa B) occurs in a biphasic manner in postischemic myocardium. Because interleukin-1 (IL-1), IL-6, tumor necrosis factor-alpha (TNF-alpha), and inducible nitric-oxide synthase (iNOS) contain kappa B-response elements, and since transforming growth factor-beta 1 (TGF-beta 1) down-modulates both cytokine and iNOS expression, we studied their temporal expression during myocardial ischemia/reperfusion (I/R). Northern and Western analyses showed low levels of IL-6 and no signal for IL-1 beta, TNF-alpha and iNOS under basal conditions. Their expression rose significantly over sham-operated controls by 1 h reperfusion, and persisted high for various periods. Under basal conditions, low levels of TGF-beta 1 were detected, which rose significantly at 3 h reperfusion, and remained high until 24 h reperfusion. Administration of diethyldithiocarbamate (DDC) inhibited induction of NF-kappa B and concomitantly the expression of IL-1 beta, IL-6, TNF-alpha as well as iNOS. However, expression of TGF-beta was not altered. Our results indicate that ischemia/reperfusion induces NF-kappa B, and upregulates kappa B-response genes. Administration of DDC inhibits NF-kappa B le...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Sep 1, 1992·Research in Immunology·P B Sehgal
Dec 1, 1992·Circulation·R Bolli
Jan 1, 1992·Free Radical Research Communications·R SchreckP A Baeuerle
Jul 1, 1992·The Journal of Clinical Investigation·W A Border, E Ruoslahti
May 1, 1990·Molecular and Cellular Biology·T A Libermann, D Baltimore
Jan 1, 1990·Annals of the New York Academy of Sciences·M B Sporn, A B Roberts
Nov 8, 1985·Science·L J Old
Sep 1, 1989·Circulation Research·I J BenjaminW A Clark
Aug 3, 1989·The New England Journal of Medicine·A F SuffrediniJ E Parrillo
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A C NolanR Zak
Apr 6, 1995·Biochemical and Biophysical Research Communications·C E GoldringJ F Jeannin
Aug 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·H SatoJ Vinten-Johansen
Apr 1, 1995·Clinical and Experimental Pharmacology & Physiology·J R WoodgettJ M Kyriakis
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A GellerT R Billiar
Aug 1, 1993·The Journal of Experimental Medicine·Y VodovotzC Nathan
Dec 1, 1994·Free Radical Biology & Medicine·S MankhetkornC Houee-Levin
Nov 1, 1994·The Journal of Experimental Medicine·S M Wahl
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A M LeferR Scalia
Jun 14, 1996·Biochemical and Biophysical Research Communications·B ChandrasekarG L Freeman
Sep 1, 1996·Circulation Research·R A KellyT W Smith
Jun 1, 1996·Journal of Molecular and Cellular Cardiology·J C PlumierR W Currie
Jun 1, 1996·Free Radical Research·J LiuB N Ames

❮ Previous
Next ❯

Citations

Dec 24, 2004·Acta Neuropathologica·Yun-Hong DingYuchuan Ding
Dec 9, 2003·European Journal of Pharmacology·Prabal K ChatterjeeChristoph Thiemermann
Feb 24, 2001·The Annals of Thoracic Surgery·G ValenJ Vaage
Jul 24, 2001·The Annals of Thoracic Surgery·T SaitoA Giaid
Nov 19, 2002·Biochemical and Biophysical Research Communications·Lin XuXinkang Wang
Jul 23, 2003·The Journal of Surgical Research·Stewart M LongIrving L Kron
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·B J PomerantzC A Dinarello
Jan 24, 2009·The Journal of Biological Chemistry·Kaliyamurthi VenkatachalamBysani Chandrasekar
Jul 10, 2009·Cardiovascular Research·Zhijuan CaoYuehua Li
Apr 22, 2003·Infection and Immunity·Huan HuangHerbert B Tanowitz
Oct 29, 2000·Annals of the Rheumatic Diseases·C A Dinarello
Jul 11, 2000·Clinical and Experimental Immunology·B ChandrasekarG L Freeman
Feb 9, 2006·Neurological Research·Yuchuan Ding, Justin C Clark
Nov 16, 2001·Journal of Molecular and Cellular Cardiology·J ChenG L Freeman
Jul 5, 2005·Expert Opinion on Investigational Drugs·K J KallenS Rose-John
Mar 5, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yasin BayirZekai Halici
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Anna CargnoniRoberto Ferrari
Sep 3, 2013·Journal of Immunological Methods·Faas H van DoorenAnje A te Velde
Jan 25, 2007·Asian Cardiovascular & Thoracic Annals·Li-Zhong WangZheng-Ping Wang
Jun 12, 2009·Asian Cardiovascular & Thoracic Annals·Race L KaoChuanfu Li
Oct 30, 2008·Molecular Pain·Andre LaferrièreTerence J Coderre
Feb 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Maria BrownW Keith Jones
May 30, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Geeta D ThakkerChristie M Ballantyne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.