Inhibition of nuclear translocation of notch intracellular domain (NICD) by diosgenin prevented atherosclerotic disease progression

Biochimie
Ambika BineshHalagowder Devaraj

Abstract

Notch signaling plays a pivotal role in homeostasis and cardiovascular development. The role of notch signaling in atherosclerosis cannot be complete without analysing the key role of notch in macrophages, which trigger the inflammatory response and subsequent plaque formation in atherosclerosis. Diosgenin showed its anti-atherosclerotic property by the unifying mechanism of suppressing the expression of notch signaling pathway, particularly the nuclear translocation of notch intracellular domain (NICD) in aorta and in differentiated macrophage cells. It is further confirmed by the inhibition of NICD by DAPT (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester), which also restricted the differentiation of macrophage. Hence, inhibition of nuclear translocation of NICD by diosgenin aids in preventing atherosclerosis.

Citations

Nov 7, 2019·Food & Function·Fang-Chun Wu, Jian-Guo Jiang
Jan 12, 2020·Journal of Biochemical and Molecular Toxicology·Ambika BineshDevaraj Halagowder
Jan 10, 2020·Oxidative Medicine and Cellular Longevity·Giorgio AquilaPaola Rizzo
Sep 27, 2019·Pharmacological Reviews·Dongdong WangAtanas G Atanasov
May 1, 2021·International Journal of Molecular Sciences·Rosaria Vincenza GiglioManfredi Rizzo
Oct 12, 2021·Medical Oncology·Kumud Nigam, Ratnesh Kumar Srivastav

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