Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral Probiotic

Journal of Agricultural and Food Chemistry
Adelaida Esteban-FernándezM Victoria Moreno-Arribas

Abstract

Several benefits have been described for red wine polyphenols and probiotic strains in the promotion of colonic metabolism and health. On the contrary, knowledge about their role in the management of oral health is still scarce. In this work, the antiadhesive capacity of selected red wine polyphenols and oenological extracts against the oral pathogens Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mutans in an in vitro model of human gingival fibroblasts has been explored as well as their complementary action with the candidate oral probiotic Streptococcus dentisani. Results highlighted the antiadhesive capacity of caffeic and p-coumaric acids as well as grape seed and red wine oenological extracts. Both, caffeic and p-coumaric acids increased their inhibition potential against S. mutans adhesion when combined with S. dentisani. Additionally, UHPLC-MS/MS analysis demonstrated the oral metabolism of wine phenolics due to both, cellular and bacterial activity.

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Citations

Jan 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaopu RenGuanghong Zhou
May 11, 2018·Clinical and Experimental Dental Research·Asbjorn Jokstad
May 22, 2019·Journal of Periodontology·Adelaida Esteban-FernándezAlex Mira
Jun 23, 2019·BMC Complementary and Alternative Medicine·María C SánchezDavid Herrera
Oct 15, 2020·Nutrients·M Victoria Moreno-ArribasMaria José Motilva
Mar 7, 2021·Microorganisms·María Carmen SánchezMariano Sanz
Nov 6, 2021·Critical Reviews in Food Science and Nutrition·Zhenyu WangZhiyong He

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