Inhibition of ornithine decarboxylase by ifenprodil

European Journal of Pharmacology
L BadoloM Hanocq

Abstract

Ifenprodil (NMDA receptor antagonist) was tested as an inhibitor of ornithine decarboxylase. It was found that ifenprodil inhibited ornithine decarboxylase activity with the same potency as alpha-difluoromethylornithine, a major inhibitor of ornithine decarboxylase. This result suggests that ifenprodil could target either the polyamine site on the NMDA receptor complex or/and polyamine biosynthesis.

References

Jan 1, 1991·Life Sciences·K WilliamsP B Molinoff

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