Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation

Biochemical and Biophysical Research Communications
J SchindlerP P McCann

Abstract

Murine embryonal carcinoma cells can be induced to differentiate in vitro by various physical and chemical means. We report here that inhibition of ornithine decarboxylase activity with a specific enzyme-activated inhibitor, alpha-difluoromethylornithine, can induce differentiation in embryonal carcinoma cells. The differentiated phenotype can be distinguished from undifferentiated embryonal carcinoma cells by altered cellular morphology, biochemical and cell surface antigenic properties. These results suggest that alterations in the levels of cellular polyamines may play a role in embryonal carcinoma cell differentiation.

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Citations

Jan 1, 1984·Advances in Enzyme Regulation·O HebyM Kanje
Jan 1, 1985·Advances in Enzyme Regulation·O Heby
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