Inhibition of P2X(7) receptors by divalent cations: old action and new insight.

European Biophysics Journal : EBJ
Lin-Hua Jiang

Abstract

P2X family receptors form ATP-gated ion channels by assembling homo/hetero-trimers from seven receptor subunits. The homomeric P2X(7) receptor is extraordinary in that in addition to distinctive localization and biological functions it exhibits several hallmark properties, for example, the receptor is potently inhibited by divalent cations such as calcium, magnesium, zinc and copper. Despite the fact that this distinct feature was first described almost three decades ago, our understanding is still contentious. Recent site-directed mutagenesis studies have provided direct evidence showing that functional inhibition by zinc and copper primarily results from direct interaction with the receptor. In this short review, I will give a concise description of the major localization, biological functions, and unique properties of the P2X(7) receptor, and particularly discuss the evolving understanding of how divalent cations inhibit the P2X(7) receptor and the potential implication of such inhibition to the physiological and pathophysiological role of the P2X(7) receptor.

References

Jan 1, 1985·General Pharmacology·G Burnstock, C Kennedy
Jan 15, 1986·The Biochemical Journal·J L Gordon
May 1, 1974·Acta Pharmacologica Et Toxicologica·R Dahlquist, B Diamant
Jun 15, 1980·The Biochemical Journal·S Cockcroft, B D Gomperts
Feb 28, 1997·The Journal of Biological Chemistry·F RassendrenA Surprenant
Apr 23, 1997·European Journal of Pharmacology·K Nakazawa, Y Ohno
Nov 19, 1997·Neuropharmacology·C VirginioA Surprenant
Apr 29, 1998·British Journal of Pharmacology·S S WildmanG Burnstock
May 20, 1998·The American Journal of Clinical Nutrition·S S Percival
Apr 3, 1999·British Journal of Pharmacology·S S WildmanG Burnstock
May 13, 1999·Journal of Neurophysiology·K XiongC Li
Oct 8, 1999·British Journal of Pharmacology·S S WildmanG Burnstock
Oct 12, 1999·The Journal of Physiology·F M SmithR D Murrell-Lagnado
Nov 24, 1999·The Journal of Biological Chemistry·O R BaricordiF Di Virgilio
Nov 24, 1999·The Journal of Membrane Biology·S Ding, F Sachs
Mar 29, 2000·Journal of Neurochemistry·C Acuña-CastilloJ P Huidobro-Toro
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·R A North, A Surprenant
Oct 4, 2000·The Journal of Biological Chemistry·M SolleC A Gabel
Oct 13, 2000·Biochimica Et Biophysica Acta·M KlapperstückF Markwardt
Mar 21, 2001·Nature Reviews. Neuroscience·B S Khakh
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B C SuhK T Kim
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L C DenlingerP J Bertics
Nov 15, 2001·The EMBO Journal·M KimA Surprenant
Dec 1, 2001·Immunity·A MacKenzieA Surprenant
Mar 8, 2002·The Journal of Physiology·J Dylan ClyneRichard I Hume
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeffrey M LabasiChristopher A Gabel
Jul 11, 2002·The Journal of Biological Chemistry·Heather L WilsonR Alan North
Sep 25, 2002·Physiological Reviews·R Alan North
Jul 15, 2003·Molecular Biology of the Cell·Anna MorelliFrancesco Di Virgilio
May 6, 2004·The Journal of Biological Chemistry·Séverine ChaumontFrancois Rassendren
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiang-Ping ChuZhi-Gang Xiong
Nov 24, 2004·Trends in Pharmacological Sciences·Catherine VialRichard J Evans
May 19, 2005·The Journal of Biological Chemistry·Naomi NagayaRichard I Hume

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Citations

Jan 26, 2011·The Journal of Biological Chemistry·Wolfgang NörenbergMichael Schaefer
Sep 14, 2011·The Journal of General Physiology·Zonghe YanStanko S Stojilkovic
Nov 22, 2011·PLoS Pathogens·Catherine M MillerNicholas C Smith
Aug 16, 2013·Antioxidants & Redox Signaling·Stanko S StojilkovicClaudio Coddou
Sep 21, 2011·Journal of Molecular Neuroscience : MN·V PoornimaAmal Kanti Bera
Feb 10, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Takato TakenouchiMakoto Hashimoto
Apr 2, 2013·Journal of Psychiatric Research·Harald Murck
Oct 13, 2011·Tissue Antigens·J S WileyS J Fuller
Sep 17, 2013·Journal of Cellular Physiology·Adolfo E CuadraJosé R Lemos
Aug 25, 2015·Frontiers in Immunology·Sharifah Alawieyah Syed MortadzaLin-Hua Jiang
Jun 4, 2013·Neuropharmacology·Nanette MessemerPatrizia Rubini
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mufeng LiKenton J Swartz
Dec 3, 2014·European Journal of Pharmacology·Jesús Sánchez-NogueiroAntonio R Artalejo
Mar 3, 2017·Biological & Pharmaceutical Bulletin·Makiko FujiwaraKazuki Nagasawa
Jul 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chengfei ZhangBing Du
Feb 26, 2010·Journal of Neurochemistry·Susanna AlloisioMario Nobile
Mar 27, 2015·Clinical Psychology & Psychotherapy·António P RibeiroInes Sousa
Jun 15, 2014·Pharmacological Reviews·Rachael BartlettRonald Sluyter
Jun 4, 2011·Pflügers Archiv : European journal of physiology·Sarah KesslerMartin Fronius
Feb 18, 2017·Frontiers in Neuroscience·Edward BeamerTobias Engel
Feb 4, 2015·The Journal of Biological Chemistry·Xin LiangTerrance M Egan
Jul 17, 2020·International Journal of Molecular Sciences·Elizabeth Rivas-YáñezDaniela Sauma
Jul 14, 2018·Frontiers in Chemistry·Chris N J Young, Dariusz C Górecki
Apr 24, 2021·Frontiers in Cellular Neuroscience·Paul R Territo, Hamideh Zarrinmayeh

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