Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D

Cancer Research
Larisa NonnDonna M Peehl

Abstract

Although numerous studies have implicated vitamin D in preventing prostate cancer, the underlying mechanism(s) remains unclear. Using normal human prostatic epithelial cells, we examined the role of mitogen-activated protein kinase phosphatase 5 (MKP5) in mediating cancer preventive activities of vitamin D. Up-regulation of MKP5 mRNA by 1,25-dihydroxyvitamin-D3 (1,25D) was dependent on the vitamin D receptor. We also identified a putative positive vitamin D response element within the MKP5 promoter that associated with the vitamin D receptor following 1,25D treatment. MKP5 dephosphorylates/inactivates the stress-activated protein kinase p38. Treatment of prostate cells with 1,25D inhibited p38 phosphorylation, and MKP5 small interfering RNA blocked this effect. Activation of p38 and downstream production of interleukin 6 (IL-6) are proinflammatory. Inflammation and IL-6 overexpression have been implicated in the initiation and progression of prostate cancer. 1,25D pretreatment inhibited both UV- and tumor necrosis factor alpha-stimulated IL-6 production in normal cells via p38 inhibition. Consistent with inhibition of p38, 1,25D decreased UV-stimulated IL-6 mRNA stabilization. The ability of 1,25D to up-regulate MKP5 was mainta...Continue Reading

References

Dec 1, 1988·The American Journal of Surgical Pathology·J E McNealT A Stamey
Jun 1, 1995·The Journal of Clinical Investigation·T BellidoS C Manolagas
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·J S RhimG Jay
Jul 3, 1999·The Journal of Biological Chemistry·T TanoueE Nishida
Nov 4, 2000·Cytogenetics and Cell Genetics·K MasudaY Matsuda
Dec 6, 2001·The American Journal of Pathology·D GiriM Ittmann
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 5, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P W HochachkaP Kozlowski
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
May 3, 2003·Methods in Molecular Medicine·Donna M Peehl
Jan 7, 2004·Biochemical and Biophysical Research Communications·Aleksandar RadonićAndreas Nitsche
Jan 21, 2004·Cancer Letters·Dharam P ChopraRaymond R Mattingly
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Philippe P Roux, John Blenis
Jul 15, 2004·Current Opinion in Pharmacology·Jeremy Saklatvala
Sep 18, 2004·International Journal of Epidemiology·Leticia FernándezCarlos González
Oct 23, 2004·Carcinogenesis·Ganesh S PalapattuWilliam G Nelson
Nov 13, 2004·The Journal of Urology·William G NelsonWilliam B Isaacs
Nov 24, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Donna M PeehlDavid Feldman
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sungtae KimJ Wesley Pike
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth A PlatzH Ballentine Carter
Mar 25, 2005·Endocrine-related Cancer·D M Peehl
Apr 9, 2005·The Journal of Investigative Dermatology·Jianfen LuSunil Nagpal
Apr 13, 2005·Journal of Human Genetics·Shanhai XuAkira Horii
Apr 16, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Toru FurukawaAkira Horii
Apr 20, 2005·Journal of Cellular Biochemistry·Zoran CuligAlfred Hobisch
Jun 28, 2005·International Journal of Cancer. Journal International Du Cancer·Hanna E RauhalaTapio Visakorpi
Aug 12, 2005·The Journal of Biological Chemistry·Xiaohui ZhangWenlong Bai
Apr 26, 2008·Endocrine Reviews·Stephanie T PageWilliam J Bremner

❮ Previous
Next ❯

Citations

Apr 18, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D GaoC Bing
Nov 12, 2013·Antioxidants & Redox Signaling·Pablo RíosRafael Pulido
Jan 16, 2013·Endocrine-related Cancer·Carlien LeyssensAnnemieke Verstuyf
Apr 8, 2014·Nature Reviews. Cancer·David FeldmanBrian J Feldman
Jan 19, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Aruna V KrishnanDavid Feldman
Oct 13, 2010·Annual Review of Pharmacology and Toxicology·Aruna V Krishnan, David Feldman
Oct 13, 2011·Advances in Preventive Medicine·Krishna Vanaja Donkena, Charles Y F Young
Aug 30, 2008·Wiener klinische Wochenschrift·Natalie SampsonPeter Berger
Sep 12, 2012·Cancer Investigation·Gabriela PicottoNori Tolosa de Talamoni
Mar 5, 2016·Frontiers in Immunology·Ken BataiRick A Kittles
Feb 26, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P SrikanthUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Nov 21, 2012·Journal of Diabetes and Its Complications·Shahzaib AhmadBarbara J Boucher
Apr 25, 2012·Rheumatic Diseases Clinics of North America·Aruna V KrishnanDavid Feldman
Sep 14, 2011·Neuroscience Letters·Donald J LehmannA David Smith
Aug 2, 2011·Molecular and Cellular Endocrinology·Heide S CrossEnikö Kallay
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·E VanoirbeekA Verstuyf
Jul 2, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ana Diez-SampedroAlessia Fornoni
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·Aruna V KrishnanDavid Feldman
Feb 17, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Aruna V KrishnanDavid Feldman
Apr 23, 2009·Journal of Cellular and Molecular Medicine·Darja ObradovicTheo Rein
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Aruna V KrishnanDavid Feldman
Aug 23, 2008·European Journal of Clinical Investigation·Y TalmorG Rashid
Feb 27, 2008·The FEBS Journal·Rafael Pulido, Rob Hooft van Huijsduijnen
Jan 3, 2013·Journal of Biochemical and Molecular Toxicology·Gregory A GoldenJill A Poole
Jul 7, 2011·International Journal of Cancer. Journal International Du Cancer·Ryoko OkamotoH Phillip Koeffler
Aug 25, 2010·Journal of Periodontal Research·S JabbarS P Tuck
Oct 16, 2012·Molecular Nutrition & Food Research·Julie MarcotorchinoJean-François Landrier
Nov 22, 2013·Journal of Periodontal Research·S H SteinD A Tipton
Jan 24, 2015·Basic & Clinical Pharmacology & Toxicology·Tuija HömmöRiku Korhonen
Dec 16, 2011·The Biochemical Journal·James C FleetYan Li
Dec 12, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Bruce W HollisSebastiano Gattoni-Celli
Oct 2, 2013·American Journal of Obstetrics and Gynecology·Lai XuJames M Roberts
Jul 30, 2014·Frontiers in Physiology·Thea K WöbkeDieter Steinhilber
May 26, 2016·Cellular and Molecular Life Sciences : CMLS·Eva KassiAthanasios G Papavassiliou
May 31, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Arend Jan NieuwlandJan H N Lindeman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.