PMID: 9445014Jan 28, 1998Paper

Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein

Journal of Virology
C A Pise-MasisonJ N Brady

Abstract

Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent for adult T-cell leukemia. HTLV-1 transforms lymphocytes, and there is increasing evidence that the virus-encoded protein, Tax, plays a primary role in viral transformation. We have shown that wild-type p53 in HTLV-1-transformed cells is stabilized. This study was initiated to directly analyze whether the p53 in HTLV-1-transformed cell lines was transcriptionally active and to identify the viral gene product responsible for stabilization and inactivation. Transfection experiments using a p53-responsive reporter plasmid and gamma-irradiation studies demonstrate that the wild-type p53 in HTLV-1-transformed cell lines is not fully active. Further, we demonstrate that the HTLV-1-transforming protein, Tax, stabilizes and inactivates p53 function. Cotransfection of Tax with p53 results in a greater than 10-fold reduction in p53 transcription activity. Using Ga14-p53 fusion proteins, we demonstrate that Tax inhibition of p53 transactivation function is independent of sequence-specific DNA binding. Moreover, Tax inhibits p53 function by interfering with the activity of the N-terminal activation domain (amino acids 1 to 52). We conclude that Tax is involved in the in...Continue Reading

References

Apr 1, 1992·Nature Genetics·W S el-DeiryB Vogelstein
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S J KuerbitzM B Kastan
Sep 11, 1992·Nucleic Acids Research·F KashanchiJ N Brady
Feb 1, 1992·British Journal of Cancer·N ChandarJ Novak
Dec 1, 1991·Japanese Journal of Cancer Research : Gann·H NagaiM Shimoyama
Oct 1, 1990·Molecular and Cellular Biology·J Cheng, M Haas
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A TanakaM Hatanaka
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R GrassmannW A Haseltine
Dec 1, 1987·Molecular and Cellular Biology·W DeppertT Steinmayer
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M FujiiI M Verma
May 3, 1986·Lancet·M OsameM Tara
Aug 1, 1987·Experimental Cell Research·K Snow, W Judd
Feb 1, 1987·Molecular and Cellular Biology·J R de WetS Subramani
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Dec 1, 1995·The Journal of Biological Chemistry·M N UittenbogaardJ K Nyborg
Jul 1, 1993·Molecular and Cellular Biology·J ChenA J Levine
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·W J GrossmanL Ratner
Apr 1, 1993·Genes & Development·C Prives, J J Manfredi
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Y ChenM B Kastan
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M E PerryA J Levine
Jul 1, 1993·Genes & Development·X WuA J Levine
Jan 1, 1993·Japanese Journal of Cancer Research : Gann·K YamatoI Miyoshi
May 1, 1996·Genes & Development·L J Ko, C Prives

❮ Previous
Next ❯

Citations

Sep 30, 1999·Transfusion·W H Dzik, A Okayama
Oct 3, 1999·Current Opinion in Oncology·E Cesarman, E A Mesri
Nov 18, 2000·AIDS Research and Human Retroviruses·Y L KuoC Z Giam
Mar 13, 2001·Annual Review of Immunology·M Yoshida
Feb 15, 2002·The Journal of Biological Chemistry·Thorsten StieweBrigitte M Pützer
Aug 12, 2003·Oncogene·Michael L GatzaSusan J Marriott
Sep 13, 2005·Oncogene·Ralph GrassmannKuan-Teh Jeang
Oct 6, 2007·International Journal of Cancer. Journal International Du Cancer·Yana Schavinsky-KhrapunskyMordechai Aboud
Dec 21, 2012·Reviews in Medical Virology·Yoshitaka Sato, Tatsuya Tsurumi
Jan 10, 2002·The Journal of Biological Chemistry·Jill A LivengoodJennifer K Nyborg
Jul 9, 2002·Oncogene·Keng-Hsin LanShou-Dong Lee
Dec 10, 1999·The Journal of Biological Chemistry·M UenoT Nikaido
Nov 18, 2000·AIDS Research and Human Retroviruses·X H Li, R B Gaynor
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Christophe DebacqLuc Willems
Jul 4, 2001·The Journal of Biological Chemistry·F J Lemoine, S J Marriott
Dec 2, 2008·Nature Reviews. Drug Discovery·Anwesha DeyDavid P Lane
Jul 15, 2015·Journal of Oncology·Christophe Nicot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.