PMID: 193153Apr 1, 1977

Inhibition of PGE1-stimulated cAMP accumulation in human platelets by thromboxane a2

Prostaglandins
O V MillerR R Gorman

Abstract

The prostaglandin endoperoxide PGH2, HHT, HETE, thromboxane A2, and thromboxane B2, which are all products of arachidonic acid metabolism of human platelets, were tested for their ability to modulate platelet cyclic nucleotide levels. None of the compounds tested altered the basal level of cAMP or cGMP, and only PGH2 and thromboxane A2 inhibited PGE1-stimulated cAMP accumulation. Thromboxane A2 was found to be a more potent inhibitor of PGE1-stimulated cAMP accumulation and inducer of platelet aggregation than PGH2.

Citations

Dec 1, 1976·Prostaglandins·N WhittakerF F Sun
Dec 1, 1989·Prostaglandins·T W WilsonT A Waslen
Sep 1, 1984·Prostaglandins, Leukotrienes, and Medicine·M A LazzariM Gimeno
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R R GormanF A Fitzpatrick
Dec 3, 1984·European Journal of Biochemistry·K Aktories, K H Jakobs
Apr 1, 1979·The Journal of Clinical Investigation·S Rittenhouse-Simmons
Nov 7, 1977·Biochemical and Biophysical Research Communications·R R GormanO V Miller
Nov 21, 1977·Biochemical and Biophysical Research Communications·T V ZenserB B Davis
Jan 1, 1980·CRC Critical Reviews in Biochemistry·R J Gryglewski

Related Concepts

Cyclic AMP, (R)-Isomer
Blood Platelets
Cyclic GMP
Hydroxy Acids
Microsomes
Peroxides
Platelet Aggregation
Prostaglandins E
Pyrans

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.