PMID: 193153Apr 1, 1977

Inhibition of PGE1-stimulated cAMP accumulation in human platelets by thromboxane a2

O V MillerR R Gorman


The prostaglandin endoperoxide PGH2, HHT, HETE, thromboxane A2, and thromboxane B2, which are all products of arachidonic acid metabolism of human platelets, were tested for their ability to modulate platelet cyclic nucleotide levels. None of the compounds tested altered the basal level of cAMP or cGMP, and only PGH2 and thromboxane A2 inhibited PGE1-stimulated cAMP accumulation. Thromboxane A2 was found to be a more potent inhibitor of PGE1-stimulated cAMP accumulation and inducer of platelet aggregation than PGH2.


Dec 1, 1976·Prostaglandins·N WhittakerF F Sun
Dec 1, 1989·Prostaglandins·T W WilsonT A Waslen
Sep 1, 1984·Prostaglandins, Leukotrienes, and Medicine·M A LazzariM Gimeno
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R R GormanF A Fitzpatrick
Dec 3, 1984·European Journal of Biochemistry·K Aktories, K H Jakobs
Apr 1, 1979·The Journal of Clinical Investigation·S Rittenhouse-Simmons
Nov 7, 1977·Biochemical and Biophysical Research Communications·R R GormanO V Miller
Nov 21, 1977·Biochemical and Biophysical Research Communications·T V ZenserB B Davis
Jan 1, 1980·CRC Critical Reviews in Biochemistry·R J Gryglewski

Related Concepts

Cyclic AMP, (R)-Isomer
Blood Platelets
Cyclic GMP
Hydroxy Acids
Platelet Aggregation
Prostaglandins E

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