PMID: 9536954Apr 16, 1998Paper

Inhibition of phenolsulphotransferase by salicylic acid: a possible mechanism by which aspirin may reduce carcinogenesis

Gut
R M HarrisR H Waring

Abstract

Recent epidemiological evidence has shown that chronic use of aspirin decreases susceptibility to bowel cancer. Animal studies have shown that sulphotransferase inhibitors coadministered with sulphation activated carcinogens dramatically reduce the incidence of cancer. To investigate the effect of the main aspirin breakdown product, salicylic acid, on the P and M isoforms of phenolsulphotransferase from human platelets and colonic mucosa. Platelets were obtained from healthy blood donors and isolated within 24 hours after donation. Samples of colonic mucosa were obtained at resection for non-malignant disease. Phenolsulphotransferase activity was measured in cellular homogenates using a standard radiolabelling assay. Salicylic acid consistently and selectively inhibited the P form of phenolsulphotransferase at subtherapeutic concentrations in both tissue samples. A 50% inhibition of sulphation by the P phenolsulphotransferase occurred at salicylic acid concentrations of about 40 and 130 microM in platelets and bowel mucosa respectively. M phenolsulphotransferase was virtually unaffected by salicylic acid up to a concentration of 1.5 mM (the therapeutic plasma concentration for salicylates when treating rheumatoid arthritis is a...Continue Reading

References

Jan 1, 1979·Drug Metabolism Reviews·G Levy
Dec 15, 1991·The New England Journal of Medicine·M J ThunC W Heath
Mar 6, 1991·Journal of the National Cancer Institute·L RosenbergS Shapiro
Oct 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P L Grover
Mar 1, 1985·Clinical Pharmacokinetics·C J Needs, P M Brooks
Dec 19, 1973·Biochimica Et Biophysica Acta·A Foldes, J L Meek
Mar 1, 1972·Journal of Pharmaceutical Sciences·M RowlandS D Sholkoff
Apr 11, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·R J Anderson, R M Weinshilboum
Sep 7, 1995·The New England Journal of Medicine·E GiovannucciF E Speizer
Jun 2, 1993·Journal of the National Cancer Institute·E R GreenbergR Haile
Dec 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R M Harris, R H Waring

❮ Previous
Next ❯

Citations

Oct 25, 2008·Critical Reviews in Food Science and Nutrition·Gregory Tucker, Kevin Robards
Nov 6, 2013·Drug Metabolism Reviews·Margaret O James, Sriram Ambadapadi
Sep 15, 2005·International Journal of Cancer. Journal International Du Cancer·Walter MeinlHansruedi Glatt
Nov 13, 2015·Thrombosis and Haemostasis·Victor L SerebruanyMoo Hyun Kim
Mar 22, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ken Eagle
Dec 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thummaruk SuksrichavalitVirapong Prachayasittikul
Jan 5, 2000·The Journal of Biological Chemistry·R M HarrisP J Hughes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.