PMID: 9648868Jul 2, 1998Paper

Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin

Journal of Neurochemistry
Y Q Hu, P H Koo

Abstract

Monoamine-activated alpha2-macroglobulin (alpha2M) was shown to reduce the dopamine concentration in corpus striatum of adult rat brains and inhibit other neuronal functions in vivo and in vitro. As brain-derived neurotrophic factor, neurotrophin-4, and neurotrophin-3 are important neurotrophic factors for dopaminergic neurons, the effect of monoamine-activated alpha2M on signal transduction by trkB and trkC was investigated. The results show that monoamine-activated alpha2M binds to trkB and inhibits brain-derived neurotrophic factor/neurotrophin-4-promoted autophosphorylation of trkB in a dose-dependent manner in both trkB-expressing NIH3T3 (NIH3T3-trkB) and human neuroblastoma SH-SY5Y cells. Monoamine-activated alpha2M also blocks tyrosine phosphorylation of phospholipase C-gamma1 and extracellular signal-regulated protein kinase (ERK)-1, which are key intracellular proteins involved in trkB signal transduction. Similarly, monoamine-activated alpha2M inhibits tyrosine phosphorylation of neurotrophin-3-induced trkC and its signal transduction in a dose-dependent manner in NIH3T3 cells expressing trkC (NIH3T3-trkC). In contrast to monoamine-activated alpha2M, normal alpha2M has little or no significant inhibitory effect on the...Continue Reading

Citations

Sep 17, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rui GuanXiao-Yan Wen
Feb 19, 2013·Biomedit︠s︡inskai︠a︡ khimii︠a︡·N A Zorin, V N Zorina
Mar 31, 2005·The Journal of Biological Chemistry·Sylvain LesnéAlain Buisson

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