Inhibition of Phytosterol Biosynthesis by Azasterols

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Sylvain DarnetHubert Schaller

Abstract

Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development.

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Citations

Sep 16, 2020·Journal of Experimental Botany·Kjell De VrieseSteffen Vanneste
May 19, 2021·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xiaohui ZhangDengfeng Hong

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