PMID: 8968395Oct 1, 1996Paper

Inhibition of plasminogen activator inhibitor-1 activity by two diketopiperazines, XR330 and XR334 produced by Streptomyces sp

The Journal of Antibiotics
J BryansS Trew

Abstract

Two diketopiperazines, XR334 (1) and the novel compound XR330 (2), were isolated from the lyophilised biomass of an unidentified Streptomyces sp. Their structures were elucidated on the basis of spectroscopic studies and confirmed by chemical synthesis. Both compounds inhibited plasminogen activator inhibitor-1 activity in an amidolytic assay of tissue plasminogen activator mediated plasmin generation. Compound 1 also enhanced fibrinolysis ex vivo and protected against thrombus formation in the rat. These diketopiperazines represent the first low molecular weight inhibitors of plasminogen activator inhibitor-1, a physiological regulator of fibrinolysis.

Citations

Jan 27, 2015·Natural Product Reports·John W BluntMichèle R Prinsep
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yu JiangTonghui Ma
May 1, 1997·Expert Opinion on Investigational Drugs·P Charlton
Dec 25, 2012·Natural Product Reports·John W BluntMichèle R Prinsep
Oct 25, 2012·The Journal of Antibiotics·Qingbo ZhangChangsheng Zhang
Apr 6, 2017·The Journal of Antibiotics·Mingwei SunYuemao Shen
Mar 6, 2004·Journal of Thrombosis and Haemostasis : JTH·K VerbekeP J Declerck
Jun 19, 2008·Molecular Pharmacology·Lisa MathiasenPeter A Andreasen
Dec 24, 2014·Marine Drugs·Ri-Ming HuangCheng-Hai Gao
Apr 4, 2021·International Journal of Molecular Sciences·Rawan AltalhiRamzi A Ajjan
May 1, 2021·International Journal of Molecular Sciences·Niaz Mahmood, Shafaat A Rabbani
Aug 6, 2002·Bioorganic & Medicinal Chemistry Letters·Shouming WangJohn Spencer
Nov 19, 2009·Journal of Natural Products·Huijuan GuoYongsheng Che
Aug 11, 2010·Journal of Natural Products·Imke SchneemannJohannes F Imhoff
Jan 7, 2017·Chemical Reviews·Mireille MoutiezMuriel Gondry
Aug 22, 2015·Journal of Natural Products·Jessica L OchoaRoger G Linington

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