Aug 1, 1994

Inhibition of Plasmodium falciparum in vitro by human gamma delta T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
M M EllosoW P Weidanz

Abstract

As assessed by flow cytometry, human gamma delta T cells were shown here to inhibit replication of blood-stage Plasmodium falciparum in vitro in a dose-dependent fashion; no other leukocyte population tested was suppressive. Replication of intraerythrocytic stages of the parasite (rings, trophozoites, and schizonts) was not affected by coculture with gamma delta T cells nor were erythrocytes damaged by this coculture, indicating that the targets recognized by gamma delta T cells are extracellular merozoites in transit to new host erythrocytes. Moreover, parasite inhibition requires contact between gamma delta T cells and merozoites. These findings suggest that gamma delta T cells may exert a protective effect in immunity to malaria.

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Mentioned in this Paper

Flow Cytometry
T-Lymphocyte
Exertion
Merozoites
Extracellular
Coculture Techniques
Trophozoite
T-Cell Receptor gamma-Chain
Malaria, Falciparum
Malaria

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