PMID: 2484688Jan 1, 1989Paper

Inhibition of platelet activating factor-induced platelet aggregation by molsidomine, SIN-1, and nitrates in vitro and ex vivo

Journal of Cardiovascular Pharmacology
R GerzerJ M Heim

Abstract

We compared in vitro the effects of molsidomine, its active metabolite SIN-1, sodium nitroprusside, and the organic nitrates nitroglycerin, isosorbide-5-mononitrate, and isosorbide-2,5-dinitrate on platelet aggregation induced by platelet activating factor and on the activity of soluble guanylate cyclase. In addition, the effects of molsidomine and of isosorbide-5-mononitrate on ex vivo platelet function were studied. In vitro, SIN-1 and sodium nitroprusside were about 100-fold more potent activators of platelet guanylate cyclase and inhibitors of platelet activating factor-induced aggregation than the other agents. In contrast, in ex vivo experiments, not only molsidomine but also isosorbide-5-mononitrate inhibited platelet activating factor-induced aggregation. These data indicate that molsidomine, SIN-1, and organic nitrates can in vivo, like endothelium-derived relaxing factor, inhibit platelet aggregation and exert antithrombotic properties, although nitrates apparently cannot be converted in platelets to active metabolites. Since the antiaggregatory properties are observed when platelet activating factor is used as an aggregant, and since platelet activating factor-induced aggregation is only weakly influenced by inhibito...Continue Reading

Citations

Jan 1, 1997·Surgery Today·Y Nonami
Sep 15, 1993·European Journal of Pharmacology·A A WeberK Schrör
Feb 1, 1993·British Journal of Clinical Pharmacology·N H WallénP Hjemdahl
Jan 1, 1992·British Journal of Clinical Pharmacology·T F Lüscher
Sep 15, 1992·The American Journal of Cardiology·Y Y ChirkovJ D Horowitz
Apr 27, 2001·Expert Opinion on Investigational Drugs·J Geiger
May 9, 2002·Expert Opinion on Investigational Drugs·Ian L Megson, David J Webb
Jul 15, 1997·The American Journal of Cardiology·Y Y ChirkovJ D Horowitz

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