Inhibition of platelet aggregation by curdione from Curcuma wenyujin essential Oil

Thrombosis Research
Quan XiaFei-Hu Chen

Abstract

Curdione, one of the major sesquiterpene compounds from Rhizoma Curcumae, has been shown to exhibit multiple bioactive properties. In this study, we investigated the anti-platelet aggregation and antithrombotic activities of curdione with different methods both in vitro and in vivo. The purpose of the study was to explore an inhibitor of platelet aggregation, which promised to be a preventive or therapeutic agent for various vascular diseases. Curdione was isolated from the essential oil of Curcuma wenyujin using the silica gel column chromatography method. The effects of curdione on human platelet aggregation induced by thrombin (0.3 U/ml), platelet-activating factor (PAF, 0.375 μg/ml), adenosine diphosphate (ADP, 10 μM) and arachidonic acid (AA, 0.1mg/ml) were tested in vitro, and the potential mechanisms underlying such activities were investigated. We also tested the antithrombotic effect of curdione in a tail thrombosis model. Curdione preferentially inhibited PAF- and thrombin- induced platelet aggregation in a concentration-dependent manner (IC(50): 60-80 μM), whereas much higher concentrations of curdione were required to inhibit platelet aggregation induced by ADP and AA. Curdione also inhibited P-selectin expression i...Continue Reading

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Citations

Apr 9, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yang ZhouGaimei She
Dec 4, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Tian Song, Rongyue Sun
Oct 11, 2015·Chinese Journal of Integrative Medicine·Ying ZhangDa-Zhuo Shi
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Mar 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi ChenWan Liao
Apr 19, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Huangjin TongBailin Zeng
Aug 1, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yonggang YangYufang Liu

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