Inhibition of Platelet Aggregation by the Leaf Extract of Carica papaya During Dengue Infection: An In Vitro Study

Viral Immunology
Shobia ChinnappanSoundravally Rajendiran

Abstract

Dengue cases were reported to undergo platelet activation and thrombocytopenia by a poorly understood mechanism. Recent studies suggested that Carica papaya leaf extract could recover the platelet count in dengue cases. However, no studies have attempted to unravel the mechanism of the plant extract in platelet recovery. Since there are no available drugs to treat dengue and considering the significance of C. papaya in dengue treatment, the current study aimed to evaluate two research questions: First one is to study if the C. papaya leaf extract exerts its action directly on platelets and second one is to understand if the extract can specifically inhibit the platelet aggregation during dengue viral infection. Sixty subjects with dengue positive and 60 healthy subjects were recruited in the study. Platelet-rich plasma (PRP) and platelet-poor plasma were prepared from both the dengue-infected and healthy control blood samples. Effect of the leaf extract obtained from C. papaya leaves was assessed on plasma obtained as well as platelets collected from both healthy and dengue-infected individuals. Platelet aggregation was significantly reduced when leaf extract preincubated with dengue plasma was added into control PRP, whereas n...Continue Reading

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Citations

Sep 19, 2019·Archives of Virology·Agieshkumar Balakrishna PillaiSoundravally Rajendiran
Mar 23, 2020·Hematology, Transfusion and Cell Therapy·M Manasa, R Vani
May 14, 2021·Frontiers in Pharmacology·Md Moklesur Rahman SarkerIsa Naina Mohamed
May 28, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·X Y LimT Y C Tan

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

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