Inhibition of platelet-derived mitogen release by nitric oxide (EDRF)

Agents and Actions
M L BarrettJ R Vane

Abstract

Platelets exposed to thrombogenic surfaces adhere, aggregate and release mitogenic substances from their alpha-granules. Endothelium-derived relaxing factor (EDRF) which has been identified as nitric oxide (NO) has been reported to inhibit platelet aggregation. We now report that NO inhibits mitogen release from stimulated human platelets. Mitogenic activity was assayed on mouse fibroblast 3T3 cells using incorporation of 3H-thymidine. Serum from collagen-aggregated platelets significantly increased 3H-thymidine incorporation by 3T3 cells above that of serum from control platelets. Both this increase and platelet aggregation were blocked by NO and prostacyclin in a dose related manner. The inhibitory activity of NO decayed with time when incubated in platelet-free plasma at 37 degrees C, but was still detectable after 2 minutes.

References

Jul 18, 1986·Cell·R RossD F Bowen-Pope
Jan 15, 1988·JAMA : the Journal of the American Medical Association·J Abrams

❮ Previous
Next ❯

Citations

Oct 1, 1991·Clinical Cardiology·S P KarasM B Gravanis
May 12, 1994·European Journal of Pharmacology·Y KitaK Yoshida
Jan 1, 1997·Progress in Cardiovascular Diseases·G R De Meyer, A G Herman
Feb 1, 1997·International Journal of Cardiology·J KowalskiJ Paśnik
Jul 5, 1990·The New England Journal of Medicine·J R VaneR M Botting
Jan 1, 1992·Acta Anaesthesiologica Scandinavica. Supplementum·E E Anggård
Mar 1, 1991·British Heart Journal·A H Henderson
Aug 1, 1997·Thorax·A T Jones, T W Evans
May 1, 1994·Journal of Cardiac Surgery·G Welch, J Loscalzo
Feb 1, 1994·European Journal of Clinical Investigation·A S Brown, J F Martin
Oct 1, 1993·Journal of Internal Medicine·H Lagerlöf, C G Nilsson
Jul 2, 2005·Expert Opinion on Investigational Drugs·R M Goetz
Mar 30, 2000·Autoimmunity·M B Kahaleh, E C LeRoy
Jun 1, 1995·Annals of Medicine·G J Dusting, P S Macdonald
Sep 9, 2006·Endocrinology and Metabolism Clinics of North America·Martin M HartgeThomas Unger
Sep 1, 1994·Baillière's Clinical Haematology·R E Smith, J F Martin
Jun 1, 1992·The Annals of Thoracic Surgery·T SjöbergS Steen
Jun 17, 2000·Baillière's Best Practice & Research. Clinical Haematology·J F MartinA Mathur
Sep 1, 1995·American Journal of Surgery·D A RodebergV F Garcia
Dec 9, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Agrawal RohiniRandhir Singh
Jul 27, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Martin M HartgeUlrich Kintscher
Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·T D Warner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.