Inhibition of platelet factor 3 availability by prostacyclin

J HársfalviL Fésüs


Preincubation of human platelet rich plasma with PGI2 in a concentration preventing collagen induced platelet aggregation abolished also platelet factor 3 availability brought about by collagen. Following PGI2 pretreatment no second wave aggregation could be elicited by ristocetin. However, primary aggregation as well as platelet factor 3 activity were only partially inhibited in this case and the inhibitory action of PGI2 was not increased by raising its concentration. Similarly, marked but not complete inhibition of platelet factor 3 availability was obtained when kaolin was used as activating agent.


Jul 1, 1987·Thrombosis Research·J SkopálG Kovács
Mar 15, 1990·Thrombosis Research·M MahafzahJ L Ambrus


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Related Concepts

Platelet Factor 3
Platelet Aggregation
Metabolic Inhibition
Blood Coagulation Factor
Collagen Location

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