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Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

Molecular Neurobiology

Jul 13, 2017

P L WencelR P Strosznajder

Abstract

Poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs) are involved in the regulation of cell metabolism, transcription, and DNA repair. Alterations of these enzymes may play a crucial role in Alzheimer's disease (AD). Our previous results indicated that amyloid beta (Aβ) peptides an...read more

Mentioned in this Paper

ADAM10 gene
BACE1 gene
PSEN1 gene
PSEN2 gene
SIRT1 gene
SIRT4 gene
SIRT6 gene
PARP3 protein, human
Beta-Secretase
Amyloid Neuropathies
1
1
13
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Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

Molecular Neurobiology

Jul 13, 2017

P L WencelR P Strosznajder

PMID: 28698968

DOI: 10.1007/s12035-017-0646-8

Abstract

Poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs) are involved in the regulation of cell metabolism, transcription, and DNA repair. Alterations of these enzymes may play a crucial role in Alzheimer's disease (AD). Our previous results indicated that amyloid beta (Aβ) peptides an...read more

Mentioned in this Paper

ADAM10 gene
BACE1 gene
PSEN1 gene
PSEN2 gene
SIRT1 gene
SIRT4 gene
SIRT6 gene
PARP3 protein, human
Beta-Secretase
Amyloid Neuropathies
1
1
13

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