PMID: 8601724Feb 1, 1996Paper

Inhibition of polyamine synthesis alters hair follicle function and fiber composition

The Journal of Investigative Dermatology
P I Hynd, M J Nancarrow

Abstract

The activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase, two of the enzymes involved in the synthesis of the polyamines, were found to be high in follicle-rich homogenates of sheep skin, and to be responsive to the nutrition of the animal. Systemic provision of the inhibitor of ornithine decarboxylase, alpha difluoromethylornithine, markedly altered the length, diameter, and composition of the fiber, the last being accompanied by an increase in the proportion of the fiber occupied by paracortical cells and an increase in the level of mRNA encoding a cysteine-rich family of keratin proteins. The growth of wool follicles cultured in media containing alpha-difluoromethylornithine was not inhibited, even at high concentrations. In contrast, low concentrations of methylglyoxal (bis)guanylhydrazone, the inhibitor of S-adenosylmethionine decarboxylase, completely inhibited fiber growth in culture follicles. Addition of spermidine to the media overcame this inhibition but spermine had no effect. Further evidence that spermine is not required for normal follicle function was provided by incubating follicles with the specific inhibitor of spermine synthase, n-butyl-1,3-diaminopropane. This inhibitor, even at high...Continue Reading

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Citations

Dec 9, 1997·The British Journal of Dermatology·E J BatesM J Nancarrow
Jun 10, 2008·Journal of Animal Science·J van E NolteC P Mathis
Mar 25, 2000·The British Journal of Dermatology·E J BatesP I Hynd
Mar 10, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A Gritli-LindeA Linde
Aug 26, 2004·The British Journal of Dermatology·M M T Downie, T Kealey
Jul 2, 2009·Human Reproduction Update·Bulent O YildizRicardo Azziz
Aug 30, 2019·The Journal of Dermatology·Yu Ra LeeBong Chul Chung
Aug 19, 2000·Endocrine Reviews·R AzzizM E Sawaya
Jun 26, 2001·The British Journal of Dermatology·I BarajonP Castano
Nov 24, 2012·Journal of Animal Physiology and Animal Nutrition·K E MooreD Blache
Jul 13, 2006·Journal of Separation Science·Veniero GambaroGiacomo L Visconti
Jul 16, 2010·Experimental Dermatology·Yuval RamotRalf Paus
Nov 22, 2017·Histochemistry and Cell Biology·Yutaro YamamotoMasashi Shin
Dec 21, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edward J Calabrese
Sep 3, 1999·Mechanisms of Development·M J NancarrowB C Powell
Jun 9, 2001·Clinics in Dermatology·G E Rogers, P I Hynd

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