Jun 1, 1975

Inhibition of polypeptide synthesis by tRNA fractions in rat liver cell-free systems

Journal of Biochemistry
K IgarashiS Hirose

Abstract

The mechanism of inhibition of polypeptide synthesis by the addition of a tRNA fraction in a rat liver cell-free system was studied. The inhibition was found to occur at the step of aminoacyl-tRNA binding to ribosomes, in which aminoacyl-tRNA's were mainly responsible for the inhibition. The addition of EF-1 decreased the inhibition by the tRNA fraction. The tRNA fraction inhibited polypeptide synthesis in a polysome-S100 system under conditions in which poly U- and poly A-dependent polypeptide syntheses were not inhibited. The possibility that the aminoacyl-tRNA inhibitory activity functions through improper binding to the ribosomes in the polysome-S100 system is discussed.

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Mentioned in this Paper

Polyribosomes
Alkalescens-Dispar Group
Elongation Factor
MT-TA gene
Triplet Codon-amino Acid Adaptor Activity
S100B wt Allele
Transfer RNA
Protein Biosynthesis
Poly U
Poly A

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