Inhibition of porcine adipose tissue lipogenesis by beta-adrenergic agonists.

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
H J Mersmann

Abstract

1. Beta-adrenergic agonists were not effective inhibitors of lipogenesis in porcine adipose tissue slices in vitro; addition of theophylline permitted the inhibition. 2. Inhibition was increased to a greater extent by isoproterenol than epinephrine and was decreased by propranolol, therefore presumably via beta-adrenergic receptors. 3. Caffeine, isobutylmethylxanthine and theophylline all permitted inhibition of lipogenesis by beta-adrenergic agonists. 4. It is not clear whether the mechanism for this permissive action is via antagonism of the adenosine receptor, inhibition of cAMP phosphodiesterase or a combination of both. 5. Adenosine deaminase was weakly permissive, presumably through destruction of adenosine. Inhibition of lipogenesis was observed with glucose or acetate as lipogenic substrate and in the presence or absence of albumin.

References

Nov 1, 1989·Journal of Animal Science·C Y LiuS E Mills
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H J Mersmann
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H J Mersmann
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H J Mersmann
Mar 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·H J Mersmann

❮ Previous
Next ❯

Citations

Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K A AkanbiC Y Hu
Jul 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H J Mersmann
Nov 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H J Mersmann
Nov 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H J MersmannR L McNeel
Jan 1, 1997·Progress in Biophysics and Molecular Biology·M BolognesiP Ascenzi
Dec 1, 1992·The Proceedings of the Nutrition Society·T D Etherton, I Louveau

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
H J Mersmann
Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
H J Mersmann
Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
C Y HuH J Mersmann
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
L de la Hoz, R G Vernon
Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
H J Mersmann
© 2022 Meta ULC. All rights reserved