PMID: 9003344Dec 1, 1996Paper

Inhibition of preretinal and optic nerve head neovascularization in pigs by intravitreal triamcinolone acetonide

Ophthalmology
R P DanisB Ladd

Abstract

The authors tested the antiangiogenic properties of intravitreally administered triamcionolone acetonide in a pig model of preretinal neovascularization to determine the effectiveness of this therapy in preventing neovascularization. In 14 eyes of seven pigs, branch retinal vein occlusions were created in a standardized manner using photodynamic thrombosis with rose bengal dye and thermal burns from the argon green laser. Intravitreal injection of approximately 4 mg of triamcinolone acetonide was performed in one eye of each animal, and eyes were followed clinically for 12 weeks with ophthalmoscopy and fundus photography. A standardized grading system was developed to permit masked assessment of disc proliferations from fundus stereophotographs. After death, all neovascularization was confirmed histopathologically and a final grade was assigned to each eye. Statistical analysis employed use of a nonparametric test of the paired data. Significant inhibition of neovascularization was observed in triamcinolone-treated eyes (P = 0.0156). Although none of the steroid-injected eyes demonstrated clinically evident new vessels, histopathologic and photographic analysis results demonstrated fine new vessels on the optic disc in four eye...Continue Reading

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Citations

May 21, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J Fernando ArevaloAristides J Mendoza
Jul 31, 2007·Japanese Journal of Ophthalmology·Han ZhangTatsuro Ishibashi
Oct 31, 1998·Harvard Women's Health Watch
May 3, 2002·Ophthalmology·Adam MartidisCaroline Baumal
Apr 5, 2001·Progress in Retinal and Eye Research·P L PenfoldJ M Provis
Oct 16, 2004·Optometry : Journal of the American Optometric Association·Megan A HunterPhillip J Rosenfeld
Jul 1, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jost B JonasUrs Vossmerbaeumer
Nov 2, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jost B JonasFrank Schlichtenbrede
Jul 27, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lan-Hsin ChuangChi-Chun Lai
Mar 26, 2005·International Ophthalmology Clinics·Louise O'TooleCarlos Pavesio
Oct 4, 2005·International Ophthalmology Clinics·Lucia Sobrin, Donald J D'Amico
Jul 11, 2007·Retina·Yaron LangIdo Perlman
Jun 1, 2005·The British Journal of Ophthalmology·U H M SpandauJ B Jonas
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Dec 4, 2003·Acta Ophthalmologica Scandinavica·Murat KaracorluSerra Karacorlu
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Jan 5, 2006·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Peter J Kertes, Stuart G Coupland

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