Inhibition of presynaptic calcium transients in cortical inputs to the dorsolateral striatum by metabotropic GABA(B) and mGlu2/3 receptors

The Journal of Physiology
David A Kupferschmidt, David M Lovinger

Abstract

Cortical inputs to the dorsolateral striatum (DLS) are dynamically regulated during skill learning and habit formation, and are dysregulated in disorders characterized by impaired action control. Therefore, a mechanistic investigation of the processes regulating corticostriatal transmission is key to understanding DLS-associated circuit function, behaviour and pathology. Presynaptic GABA(B) and group II metabotropic glutamate (mGlu2/3) receptors exert marked inhibitory control over corticostriatal glutamate release in the DLS, yet the signalling pathways through which they do so are unclear. We developed a novel approach using the genetically encoded calcium (Ca(2+) ) indicator GCaMP6 to assess presynaptic Ca(2+) in corticostriatal projections to the DLS. Using simultaneous photometric presynaptic Ca(2+) and striatal field potential recordings, we report that relative to P/Q-type Ca(2+) channels, N-type channels preferentially contributed to evoked presynaptic Ca(2+) influx in motor cortex projections to, and excitatory transmission in, the DLS. Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2+) transients and striatal field potentials. mGlu2/3 receptor-mediated depression did not require functi...Continue Reading

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Citations

Mar 15, 2016·Frontiers in Synaptic Neuroscience·Christoph Körber, Thomas Kuner
May 26, 2018·The European Journal of Neuroscience·Nilupaer AbudukeyoumuGordon W Arbuthnott
Jan 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kari A JohnsonDavid M Lovinger
Nov 29, 2016·Frontiers in Cellular Neuroscience·Kari A Johnson, David M Lovinger
Apr 10, 2020·Frontiers in Neural Circuits·Christopher K Lafferty, Jonathan P Britt
Apr 11, 2021·Molecular Psychiatry·Junshi WangYan Dong

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