Inhibition of progression of chronic puromycin aminonucleoside nephrosis by probucol, an antioxidant.

Journal of the American Society of Nephrology : JASN
A B Magil

Abstract

Oxidants have been shown to be involved in the initiation of chronic puromycin aminonucleoside nephrosis in rats, but it is uncertain whether they have a role in the progression of this disease. Rats given a single internal jugular venous bolus of puromycin aminonucleoside (PA) develop early nephrotic syndrome that subsides after about 28 days followed by a 4-wk period of minimal proteinuria and then the development of focal glomerulosclerosis and increasing proteinuria. Fifty-two rats on a high-cholesterol diet were divided into four groups. Two groups of 16 animals each received a single internal jugular venous bolus of PA. One of these groups was started on the dietary antioxidant, probucol (1% wt/wt), 4 days after the PA injection and continued on it until termination. The remaining rats were given an internal jugular venous injection of an equivolume of normal saline. Five of these animals were also started on dietary probucol 4 days after the saline injection. At 11 days postinjection all animals given PA, whether on probucol or not, developed marked proteinuria with histologically minimal glomerular change and significant increases in intraglomerular monocyte and proliferating cell nuclear antigen counts. Forty-two days ...Continue Reading

Citations

Aug 6, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A B Abdel-NaimF F Attia
Jul 26, 2000·Acta Oto-laryngologica. Supplementum·A A AarnisaloJ Ylikoski
Apr 25, 2001·Kidney International·B Rodríguez-IturbeR J Johnson
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S NagaoJ J Grantham
Dec 10, 1999·Renal Failure·E N Wardle

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