Inhibition of proinflammatory mediators by coumaroyl lupendioic acid, a new lupane-type triterpene from Careya arborea, on inflammation-induced animal model

Journal of Ethnopharmacology
Rayhana BegumManju Sharma

Abstract

Careya arborea Roxb. (Lecythidaceae) is a large tree found throughout India in deciduous forests and grasslands. C. arborea is traditionally used in tumors, inflammation, anthelmintic, bronchitis, epileptic fits, astringents, antidote to snake-venom, skin disease, diarrhea, dysentery with bloody stools, dyspepsia, ulcer, tooth ache, and ear pain. In our previous work, the methanolic extract of Careya arborea stem bark showed significant anti-inflammatory activity. As a continuity of that work, this study aimed at the isolation and evaluation of the anti-inflammatory effect of coumaroyl lupendioic acid, a new lupane-type triterpene from Careya arborea stem bark. Further, to give an insight into the underlying mechanism of action of the compound on the modulation of proinflammatory mediators. Methanolic extract of Careya arborea stem bark was suspended in water, and sequentially fractionated with n-hexane and ethyl acetate. Further ethyl acetate fraction was subjected to medium pressure liquid chromatography (MPLC) to isolate the active molecules. The isolated compounds were characterized by the various spectral techniques namely UV, IR, 1H NMR, 13C NMR, DEPT, 1H-1H COSY, HMBC and Mass spectral techniques. In vitro COX-1 and COX-...Continue Reading

References

Jun 3, 2004·Phytotherapy Research : PTR·S Darshan, R Doreswamy

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Citations

Jul 28, 2017·International Journal of Molecular Sciences·Chih-Hao YangThanasekaran Jayakumar
Sep 10, 2017·Scientific Reports·Takatsugu OikeTakeshi Miyamoto
Mar 22, 2019·International Journal of Molecular Sciences·Ewa BębenekStanisław Boryczka

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