PMID: 7518854Aug 1, 1994Paper

Inhibition of proliferation of human melanocytes by a KIT antisense oligodeoxynucleotide: implications for human piebaldism and mouse dominant white spotting (W)

The Journal of Investigative Dermatology
R A SpritzK M Strunk

Abstract

KIT constitutes the cell surface transmembrane receptor protein tyrosine kinase for a growth factor variously termed steel factor (SLF), stem cell factor, mast cell growth factor, or Kit ligand. Inherited mutations of the KIT gene result in piebaldism in humans and dominant white spotting (W) in mice. Patches of hypopigmented skin and hair in these disorders represent regions lacking in melanocytes, the result of defective melanoblast differentiation, migration, proliferation, or survival during embryonic development. Here we show that incubation of normal human melanocytes with a KIT antisense oligodeoxynucleotide greatly inhibits cell proliferation in culture, whereas incubation with a KIT sense oligodeoxynucleotide has no effect. The KIT oligodeoxynucleotides also had little or no effect on cell survival.

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Citations

Jun 1, 1995·The British Journal of Dermatology·K A WardD S Sanders
Jun 3, 2000·Nature Genetics·M J KarkkainenD N Finegold
May 20, 2003·Pigment Cell Research·Bernhard Wehrle-Haller
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kostandinos SiderasS Percy Ivy
Mar 1, 1997·Seminars in Cutaneous Medicine and Surgery·R A Spritz
Feb 1, 1997·Pigment Cell Research·R E Boissy, J J Nordlund
May 1, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·Y ShibusawaO Ishikawa
Dec 18, 2018·Pharmacology & Therapeutics·Asuncion Martinez-AntonPascal Chanez
Jul 13, 2001·Pharmacology & Therapeutics·C J Wraight, P J White
Aug 12, 1998·The Journal of Investigative Dermatology·J M GrichnikC R Shea
Oct 31, 2021·Molecular Genetics & Genomic Medicine·Mario GorenjakUroš Potočnik
Nov 10, 2021·Animal Genetics·L BrancalionC M Wade

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