PMID: 2109734Jan 1, 1990Paper

Inhibition of prostaglandin and leukotriene generation by the plant alkaloids tetrandrine and berbamine

International Journal of Immunopharmacology
B S TehY H Thong

Abstract

We compared the effects of two bisbenzylisoquinoline compounds on leukotriene and prostaglandin generation by human monocytes and neutrophils. The results show that tetrandrine had a much greater effect than berbamine on leukotriene generation. However, both compounds were equally potent in suppression of prostaglandin generation. This inhibitory effect on prostaglandin generation can be overcome by exogenous arachidonic acid (AA), suggesting that the site of inhibition is not on the cyclooxygenase enzyme complex, but more proximally on the phospholipase-mediated release of AA from the cell membrane, similar to the action of corticosteroids. These results, together with previous findings of inhibitory effects on other inflammatory mediators such as histamine, platelet-activating-factor (PAF) and interleukin 1 (IL-1) indicate that these plant alkaloids may be useful lead compounds for the development of a new class of anti-inflammatory drugs.

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Citations

Mar 1, 1994·International Journal of Immunopharmacology·S Y LiY H Thong
Mar 1, 1994·International Journal of Immunopharmacology·S Y LiY H Thong
Oct 1, 1996·International Journal of Immunopharmacology·N Ivanovska, S Philipov
Feb 25, 2000·Journal of Ethnopharmacology·H S ChoiM W Chung
Jan 1, 1996·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·J G Xiao, G C Chiou
Jan 1, 1996·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·S X Liu, G C Chiou
Feb 24, 2016·Phytochemistry·N Bhagya, K R Chandrashekar
Aug 31, 2010·Journal of Ethnopharmacology·Deepak Kumar SemwalUsha Rawat
Jan 1, 1991·International Journal of Immunopharmacology·C W WongY H Thong
Sep 3, 2013·Toxicology and Applied Pharmacology·Jaime Ribeiro-FilhoPatrícia T Bozza
Jul 16, 2016·Pharmaceutical Biology·Shirin Marahel, Sharanaiah Umesha
May 23, 2006·International Immunopharmacology·Cláudio R Bezerra-SantosPatrícia T Bozza
Nov 5, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·S HuC S Foster
Mar 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jaime Ribeiro-FilhoPatrícia T Bozza
Feb 26, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Kug ChoiKyoungho Suk
Aug 28, 2020·Frontiers in Cellular Neuroscience·Alexandria M HudsonAllison B Coffin

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