Feb 1, 1976

Inhibition of prostaglandin biosynthesis by sulphasalazine and its metabolites

Prostaglandins
H O CollierS A Saeed

Abstract

Sulphasalazine (SZ) inhibits prostaglandin (PG) biosynthesis in vitro with a potency comparable to that of aceylsalicylate. The metabolites of SZ, sulphapyridine and 5-aminosalicylic acid, were of considerably lower potency as inhibitors of PG biosynthesis in the synthetase preparations used. Th inhibition of prostaglandin production by SZ could at least partly account for the clinical utility of sulphasalazine in ulcerative colitis. Sulphapyridine may help to maintain inhibitory concentrations of SZ by restraining bacterial breakdown of the active drug.

Mentioned in this Paper

Depression, Chemical
Sulfasalazin medac
Mesalamine
Metabolic Inhibition
Prostaglandin Production
Prostaglandins
Metabolite
Bos indicus
Anabolism
Prostaglandin Biosynthetic Process

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