PMID: 959570Apr 1, 1976Paper

Inhibition of prostaglandin F2alpha-induced reflex bradycardia and hypotension by meclofenamic acid

Prostaglandins
M C KossJ A Rieger

Abstract

Intravenous injection of prostaglandin F2alpha (4-15 mug/kg, i.v.) produces an increase in pulmonary arterial pressure in conjunction with reflex bradycardia and hypotension in the anesthetized cat. Meclofenamic acid (30 mg/kg, i.v.) inhibited the bradycardia and the reflex contribution to the systemic hypotension. Neither the PGF2alpha-induced pulmonary vasoconstriction nor the direct systemic vasodilator actions of PGF2alpha were blocked by meclofenamate. In addition, the reflex responses caused by i.v. veratrine and 5-HT were not inhibited by meclofenamate. These results suggest that meclofenamic acid selectively blocks the afferent mechanism by which PGF2alpha induces reflex bradycardia and hypotension in the cat.

References

Mar 1, 1976·British Journal of Pharmacology·M C Koss, J Nakano
Nov 10, 1974·Prostaglandins·M C Koss, J Nakano
Nov 1, 1973·European Journal of Pharmacology·M C KossJ Nakano
Sep 1, 1971·British Journal of Pharmacology·B Levy, H R Lindner
May 1, 1963·Acta Physiologica Scandinavica·E ANGGARD, S BERGSTROM

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Citations

Aug 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·P R SaxenaJ Heiligers
Apr 1, 1982·Prostaglandins, Leukotrienes, and Medicine·A L Sirén
Jan 1, 1994·Pharmacology & Toxicology·H Vapaatalo
Jun 1, 1981·Oral Surgery, Oral Medicine, and Oral Pathology·N H RoweJ L Turner
May 1, 1984·British Journal of Pharmacology·T H HintzeM J Panzenbeck
Mar 1, 1979·Prostaglandins·H KarppanenA Eskeli-Kaivosoja
Sep 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·N H RoweT J Petrick

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