PMID: 6406832Jan 1, 1983Paper

Inhibition of prostaglandin synthase activity of sheep seminal vesicular gland by human serum haptoglobin

Molecular and Cellular Biochemistry
D M JueY S Kang

Abstract

Serum haptoglobin was added to the reaction mixture of prostaglandin synthase (EC 1.14.99.1) and its inhibitory effect was studied [1-14C]Arachidonic acid was used as substrate and the enzyme activity was estimated by monitoring the radioactivity of the products after thin layer chromatography. With or without addition of hemoglobin to the reaction mixture, both the purified haptoglobin 1-1 and 2-2 showed inhibitory activity. In the presence of 5 microM hematin, however, inhibitory activity haptoglobin was not observed. Inhibition of prostaglandin synthesis in the system depended on the molar ratio of haptoglobin to hemoglobin in the reaction mixture. These results demonstrate that haptoglobin inhibits prostaglandin synthase by restricting available heme group for the enzyme activity through complexing with hemoglobin. However, haptoglobin did not inhibit completely the stimulatory effect of free hemoglobin. Relevant significant of this effect was discussed.

Citations

Nov 15, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·K G TournoyD L Clement
Sep 30, 1999·Nihon rinsho. Japanese journal of clinical medicine·Y Terano
Oct 16, 2001·Psychiatry Research·M MaesC A Altamura
Jul 1, 1996·Journal of Hepatology·H K LouagieG G Leroux-Roels
Jan 22, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Cameron G DensemBrian Keevil
Apr 1, 1985·The Journal of Experimental Medicine·S S PanterJ W Eaton
Sep 6, 2000·American Journal of Respiratory Cell and Molecular Biology·F YangJ J Coalson
Sep 14, 2012·Proteome Science·Carolina Fernández-CostaFrancisco J Blanco
Jan 1, 2002·Tobacco Induced Diseases·N BottiniA Bergamaschi
Mar 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M LangloisG Leroux-Roels
Aug 2, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Herman T DepypereMarc Dhont
Sep 11, 2013·Indian Journal of Human Genetics·Mukund R Mogarekar, Mahesh H Hampe
Aug 10, 1999·Fertility and Sterility·N BottiniN Lucarini
Dec 25, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kuo-Hsuan ChangChiung-Mei Chen
Aug 5, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sagheer AhmedMarius Moga
Feb 13, 2016·American Journal of Reproductive Immunology : AJRI·Kashmira BhusaneGeetanjali Sachdeva
Apr 20, 2012·Animal Reproduction Science·Dhafer M AzizHelga Sauerwein
Aug 7, 2007·Fertility and Sterility·Fulvia Gloria-BottiniEgidio Bottini
Jan 3, 2007·Biochemical and Biophysical Research Communications·Sheikh Arshad SaeedSagheer Ahmed
Jan 26, 2005·Immunology·Mohamed S ArredouaniJan L Ceuppens
May 4, 2007·International Journal of Laboratory Hematology·Kymberley Carter, Mark Worwood
Mar 1, 1997·Research in Veterinary Science·H NakagawaN Katoh
Apr 10, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F Gloria-BottiniE Bottini
Aug 21, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Salaheddin M MahmudUNKNOWN Biomarkers of Cervical Cancer Risk Study Team
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J O KarlssonM Toner
Mar 5, 2009·Yonsei Medical Journal·Jin-Kyung ChoIn-Sook Kim
Apr 23, 2002·Scandinavian Journal of Immunology·S M El-GhmatiE A M Stevens
Jul 15, 2020·Molecular Aspects of Medicine·Alessandra di MasiPaolo Ascenzi
Aug 2, 2003·Archives of Biochemistry and Biophysics·Luisa CiglianoPaolo Abrescia

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