PMID: 6405396Mar 1, 1983Paper

Inhibition of prostaglandin synthetases derived from neuronal and glial cells and rat renal medulla by ortho-, meta- and para-substituted aminophenolic compounds

Prostaglandins, Leukotrienes, and Medicine
J BaumannG Wurm

Abstract

Acetophenetidines, acetamidophenols, phenetidines and aminophenols substituted in o-, m- or p-position inhibit prostaglandin-synthetases originating from C 1300 mouse neuroblastoma cells (clone N2A), rat astrocytoma cells (clone C 6) and rat renal medulla. Desacetylated compounds were more potent inhibitors than their corresponding acetyl derivatives and many o- and m-analogues were more active than p-substituted structures like paracetamol (p-acetamidophenol) or phenacetin (p-acetophenetidine). When twelve o-, m- or p-aminophenolic test compounds were compared to acetylsalicyclic acid and indomethacin, o-, and p-phenetidine and o-aminophenol were as effective as acetylsalicyclic acid. All aminophenol derivatives which inhibited prostaglandin synthesis suppressed cultured nervous cell and kidney cyclo-oxygenases to similar extents. Our results suggest that aminophenolic drugs are not more effective against prostaglandin-synthetases in the CNS than against those in the periphery.

References

Jan 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·H KolbeH Herken
Apr 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G E Smith, L A Griffiths
Nov 1, 1965·The American Journal of the Medical Sciences·W T Beaver
May 1, 1966·The American Journal of the Medical Sciences·W T Beaver
May 1, 1965·Biochemical Pharmacology·E Bernhammer, K Krisch

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Citations

Jan 1, 1991·Neurochemistry International·N C SchaadM Schorderet
May 1, 1988·Thrombosis Research·J P DupinH Bernard
Sep 1, 1989·Journal of Neuroscience Research·A T ArenanderH R Herschman
Dec 1, 1992·Molecular and Chemical Neuropathology·I Bishai, F Coceani

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