Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Michio YamadaMasunori Matsuzaki

Abstract

The type 1 protein phosphatase (PP1) has been reported to be overactivated in the failing heart, leading to a depression in cardiac function. We investigated whether in vivo PP1 inhibition by myocardial gene transfer of inhibitor-2 (INH-2), an endogenous PP1 inhibitor, alleviates heart failure (HF) progression in the cardiomyopathic (CM) hamster, a well-established HF model. Adenoviral INH-2 gene delivery improved % fractional shortening of the left ventricle (LV) accompanied by reduced chamber size at 1 wk. In vivo myocardial INH-2 gene delivery induced an increase in cytosolic PP1 catalytic subunit alpha (PP1Calpha) without inducing the corresponding increase in cytosolic PP1 activity. On the other hand, INH-2 delivery induced a decrease in microsomal PP1Calpha, resulting in a preferential decrease in microsomal PP1 activity, thereby increasing in phospholamban phosphorylation at Ser16. INH-2 gene transfer alleviated brain natriuretic peptide expression, presumably reflecting improved cardiac function. Moreover, adeno-associated virus-mediated INH-2 gene delivery significantly extended the survival time for 3 mo. These results indicate that increased PP1 activity is an exacerbating factor during progression of genetic cardiom...Continue Reading

References

Aug 1, 1993·Cardiovascular Drugs and Therapy·J M Cruickshank
Apr 1, 1993·Molecular Biology Reports·G MattsonS Morgensen
Jul 1, 1993·The American Journal of Physiology·E F Bond, A M Gordon
Apr 12, 1996·Molecular and Cellular Biochemistry·S BartelH Scholz
Jan 1, 1997·Journal of Molecular and Cellular Cardiology·J NeumannN Zimmermann
Sep 18, 1999·Cell·K R Chien
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y IkedaJ Ross
Apr 25, 2000·Journal of Molecular and Cellular Cardiology·J D BisognanoD J Port
Sep 7, 2000·The Journal of Clinical Investigation·S TsubataJ A Towbin
Sep 21, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·P BokníkJ Neumann
Jan 12, 2002·The Journal of Biological Chemistry·Hiroki AokiSeigo Izumo
Jan 24, 2002·Nature·Donald M Bers
May 25, 2002·Molecular and Cellular Biology·Andrew N CarrEvangelia G Kranias
Jan 7, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ali El-ArmoucheThomas Eschenhagen
Oct 18, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Satu KärkkäinenKeijo Peuhkurinen
Nov 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ramesh C GuptaHani N Sabbah
Jul 3, 2004·Nature Reviews. Drug Discovery·Xander H T Wehrens, Andrew R Marks
Jun 25, 2005·Cardiovascular Research·Uwe KirchheferJoachim Neumann
Nov 29, 2005·Nature Medicine·Koichi YoshimuraMasunori Matsuzaki

❮ Previous
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Citations

Oct 9, 2008·Pharmaceutical Research·Ian S Blagbrough, Chiara Zara
Jul 28, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Christina A Pacak, Barry J Byrne
Oct 24, 2012·Nature Reviews. Cardiology·Changwon KhoRoger J Hajjar
Dec 4, 2012·The Journal of Biological Chemistry·Sean T DeGrandePeter J Mohler
Feb 11, 2009·Antioxidants & Redox Signaling·Mohammad N Jameel, Jianyi Zhang
May 7, 2009·Antioxidants & Redox Signaling·Ebo D de Muinck
Nov 26, 2010·Antioxidants & Redox Signaling·Belma Turan, Guy Vassort
Mar 1, 2011·Cardiovascular Research·Katrin WittköpperAli El-Armouche
Aug 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Nicole BrüchertJoachim Neumann
Jun 21, 2008·Circulation Research·Leif Erik VingeWalter J Koch
Jun 9, 2012·Circulation Research·Evangelia G Kranias, Roger J Hajjar
Feb 4, 2010·Circulation·Anne-Marie LompréAndrew R Marks
Nov 8, 2013·BMC Evolutionary Biology·Luís Korrodi-GregórioPedro J Esteves
Sep 6, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masafumi YanoMasunori Matsuzaki
Apr 21, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirotaka KawashimaHideharu Hayashi
May 26, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuhiro Ikeda, Masafumi Yano
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Persoulla Nicolaou, Evangelia G Kranias
Dec 3, 2014·Journal of Molecular and Cellular Cardiology·Kobra HaghighiEvangelia G Kranias
Jan 5, 2011·Biochemical and Biophysical Research Communications·Yasuo SuganoH Kirk Hammond
Mar 11, 2015·Journal of Atherosclerosis and Thrombosis·Susumu MatsudaMasunori Matsuzaki
Oct 27, 2015·Journal of Molecular and Cellular Cardiology·Brandon J Biesiadecki, Mark T Ziolo
Oct 14, 2008·Journal of Molecular and Cellular Cardiology·Alexander P SchwoererAli El-Armouche
Nov 12, 2009·BioFactors·Ilse VandecaetsbeekPeter Vangheluwe
Sep 21, 2013·Journal of Molecular and Cellular Cardiology·Jordi HeijmanDobromir Dobrev
Apr 7, 2009·Pharmacology & Therapeutics·Lynda M Blayney, F Anthony Lai
Nov 4, 2006·Journal of Molecular and Cellular Cardiology·Christopher H GeorgeF Anthony Lai
Mar 4, 2009·Biophysical Journal·Yasmin L HashambhoyJoseph L Greenstein
Sep 19, 2016·Journal of Molecular and Cellular Cardiology·Silvio WeberAli El-Armouche
Oct 11, 2016·Journal of Molecular and Cellular Cardiology·Ilka Lorenzen-SchmidtW Glen Pyle
Feb 3, 2018·Translational Psychiatry·Susan L McElroyJoanna M Biernacka
Jan 25, 2007·Physiological Genomics·Natale P L RolimPatricia C Brum
Dec 26, 2006·Expert Review of Cardiovascular Therapy·Carmen C Sucharov
Feb 13, 2008·Physiology·Yasuhiro IkedaKenneth R Chien
Oct 17, 2008·Physiological Reviews·Jennifer DavisJoseph M Metzger
Aug 26, 2011·Clinical Pharmacology and Therapeutics·P W J RaakeP Most

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