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Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders

bioRxiv

May 31, 2014

Bao-Hu JiXianjin Zhou

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Abstract

The t(1; 11) translocation appears to be the causal genetic lesion with 70% penetrance for schizophrenia, major depression, and other psychiatric disorders in a Scottish family. Molecular studies identified the disruption of the DISC1 (disrupted-in-schizophrenia 1) gene by chromosome tr...read more

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Protein Translocation
Schizophrenia 1 (Disorder)
Psychiatry Specialty
Protein Biosynthesis
Study
Glutamate decarboxylase 1
NMDA receptor antagonist
Schizophrenia
N-methyl-D-aspartate Receptor Antagonist [EPC]
DISC1 gene
2
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  • Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders

    bioRxiv

    May 31, 2014

    Bao-Hu JiXianjin Zhou

    PMID: 990005710

    DOI: 10.1101/005710

    Abstract

    The t(1; 11) translocation appears to be the causal genetic lesion with 70% penetrance for schizophrenia, major depression, and other psychiatric disorders in a Scottish family. Molecular studies identified the disruption of the DISC1 (disrupted-in-schizophrenia 1) gene by chromosome tr...read more

    Mentioned in this Paper

    Protein Translocation
    Schizophrenia 1 (Disorder)
    Psychiatry Specialty
    Protein Biosynthesis
    Study
    2

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