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Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders

bioRxiv

May 31, 2014

Baohu JiXianjin Zhou

Abstract

The t(1; 11) translocation appears to be the causal genetic lesion with 70% penetrance for schizophrenia, major depression, and other psychiatric disorders in a Scottish family. Molecular studies identified the disruption of the DISC1 (disrupted-in-schizophrenia 1) gene by chromosome tr...read more

Mentioned in this Paper

Hippocampus (Brain)
DISC1 gene
GAD1 gene
GRIN1 gene
Primary Cell Culture
Metabolic Inhibition
In Vivo
Nuclear Translocation
1q42
Schizophrenia 1 (Disorder)
2
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Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders

bioRxiv

May 31, 2014

Baohu JiXianjin Zhou

PMID: 990005710

DOI: 10.1101/005710

Abstract

The t(1; 11) translocation appears to be the causal genetic lesion with 70% penetrance for schizophrenia, major depression, and other psychiatric disorders in a Scottish family. Molecular studies identified the disruption of the DISC1 (disrupted-in-schizophrenia 1) gene by chromosome tr...read more

Mentioned in this Paper

Hippocampus (Brain)
DISC1 gene
GAD1 gene
GRIN1 gene
Primary Cell Culture
Metabolic Inhibition
In Vivo
Nuclear Translocation
1q42
Schizophrenia 1 (Disorder)
2

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