Inhibition of Quorum Sensing in Staphylococcus spp

Current Pharmaceutical Design
Gilles Brackman, Tom Coenye

Abstract

The Gram-positive, facultative anaerobic coccus-shaped bacteria of the genus Staphylococcus are among the most important causative agents of acute and chronic bacterial infections in humans as well as in animals. Treatment of Staphylococcus infections has become increasingly challenging due to the growing problem of antibiotic resistance. For this reason innovative antimicrobials with novel targets and modes of action are needed. Since the discovery that QS is used by Staphylococcus spp. to coordinate the expression of several genes involved in virulence, biofilm formation and pathogenicity, QS inhibition has gained increasing attention as an alternative anti-pathogenic strategy. A major advantage compared with antibiotic therapy is that QSIs are used in concentrations that do not affect bacterial growth. For this reason, it is expected that these compounds would exert less pressure towards the development of resistance. However, some important points still need to be addressed. Although several inhibitors have proven to be active antipathogenic agents in vitro and in several in vivo models, it is still unknown whether these compounds will also be useful in humans. Furthermore, several fundamental mechanisms by which the differ...Continue Reading

Citations

Feb 28, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Roberto VivasSona Jain
Mar 6, 2019·Infection and Immunity·Chance J CosgriffFrancis Alonzo
Mar 5, 2017·Essays in Biochemistry·Katharina RichterTom Coenye
Jan 14, 2020·Applied Microbiology and Biotechnology·E PaluchK Jermakow
Aug 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ziad OmranMajed Halwani
Apr 15, 2017·Applied Microbiology and Biotechnology·Katarzyna M Bocian-OstrzyckaElżbieta Katarzyna Jagusztyn-Krynicka
Oct 18, 2020·Antibiotics·Shashi B KumarOuliana Ziouzenkova
Feb 13, 2021·Frontiers in Microbiology·Manoj KumarRajnarayan R Tiwari
Sep 12, 2017·ACS Infectious Diseases·Arno Vermote, Serge Van Calenbergh

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