Inhibition of rabbit duodenal bicarbonate secretion by ulcerogenic agents: histamine-dependent and -independent effects

Gastroenterology
C P MyersKim E Barrett

Abstract

The gastroduodenal epithelium is protected from acid-peptic damage, in part, by its ability to secrete bicarbonate. Patients with duodenal ulcer disease have impaired proximal duodenal mucosal bicarbonate secretion. We have shown in vitro that histamine inhibits prostaglandin-stimulated bicarbonate secretion in rabbit duodenal mucosa via histamine H2 receptors and enteric nerves. In this study we examined whether the proulcerogenic compounds aspirin or ethanol regulate duodenal bicarbonate secretion and the involvement of histamine. Bicarbonate secretion by rabbit proximal duodenal mucosa was examined in vitro in Ussing chambers. Aspirin and ethanol decreased basal and prostaglandin-stimulated bicarbonate secretion; the latter effect was specific for prostaglandin. The inhibitory effects of the two ulcerogenic compounds were at least additive. Ranitidine and tetrodotoxin abolished the inhibitory effects on stimulated, but not basal, secretion. Aspirin and ethanol also induced release of duodenal histamine. Aspirin and ethanol act by two distinct pathways to impair duodenal bicarbonate secretion. Both agents inhibit basal secretion via a histamine-independent and neurally independent pathway while they inhibit prostaglandin E2-s...Continue Reading

References

Jul 1, 1991·Agents and Actions·L R Fitzpatrick, D L Decktor
Dec 1, 1990·Gastroenterology·W H BresnickJ I Isenberg
Oct 1, 1989·Japanese Journal of Pharmacology·H TanakaS Okabe
Mar 1, 1989·Digestive Diseases and Sciences·M G RobinsonC W Warner
Mar 1, 1986·Lancet·K SomervilleM Langman
Sep 1, 1988·Annals of Internal Medicine·M R GriffinW Schaffner
Sep 1, 1988·Gastroenterology·J A ChernerD D Metcalfe
Mar 1, 1986·Annals of Internal Medicine·D Y Graham, J L Smith
Feb 12, 1987·The New England Journal of Medicine·J I IsenbergM A Koss
Jan 1, 1985·Acta Medica Scandinavica·M VälimäkiM Salaspuro
Apr 1, 1986·Digestive Diseases and Sciences·K TakeuchiS Okabe
Feb 1, 1969·The American Journal of Digestive Diseases·P H Guth, X Kozbur
Jun 8, 1967·The New England Journal of Medicine·H W Davenport
May 1, 1996·Canadian Journal of Physiology and Pharmacology·P K DindaP Kossev
Feb 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·H SELYEM CANTIN

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Citations

Oct 1, 2009·Current Medical Research and Opinion·Neville D YeomansJørgen Naesdal
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elizabeth H KampG F Gebhart

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