Inhibition of rabbit platelet activation by lipoxygenase products of arachidonic and linoleic acid

Thrombosis Research
M C CoeneA G Herman


The hydroperoxy fatty acids, 15-hydroperoxyeicosatetraenoic acid (15-HPETE), 13-hydroperoxy and 9-hydroperoxyoctadecadienoic acid (13- and 9-HPODE) and the corresponding hydroxy compounds (15-HETE and 13-HODE) were synthesized and purified. Washed rabbit platelets were incubated with these fatty acid derivatives before aggregation was induced. Arachidonic acid-induced aggregation, as well as the secretion of ATP and the formation of thromboxane B2 (TXB2) were dose-dependently inhibited by these compounds. Low thrombin-, collagen- and ADP-induced aggregations were also suppressed by 15-HPETE. Platelet activation induced by the calcium ionophore A23187 and by high thrombin concentrations were not affected by 15-HPETE. In addition, doses of 15-HPETE which were inactive by themselves, potentiated the anti-aggregating activity of prostacyclin (PGI2). It is suggested that the hydroperoxy and hydroxy compounds suppress platelet activation by interference with the rise in cytoplasmic calcium in addition to the inhibition of cyclo-oxygenase.


Aug 28, 1979·Biochemical and Biophysical Research Communications·M I SiegelP Cuatrecasas
Oct 1, 1977·The Journal of Clinical Investigation·I F CharoT C Detwiler
Feb 20, 1975·Biochimica Et Biophysica Acta·D H Nugteren
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Feb 28, 1985·Biochemical and Biophysical Research Communications·A BabaH Iwata
Apr 25, 1985·Biochimica Et Biophysica Acta·P HenrikssonU Diczfalusy
Apr 11, 1980·European Journal of Pharmacology·H BultA G Herman
Apr 30, 1981·Biochemical and Biophysical Research Communications·M LagardeM Dechavanne
Jan 1, 1980·Prostaglandins·J M BoeynaemsW C Hubbard

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Feb 9, 1993·European Journal of Pharmacology·M J Van DiestA G Herman
Sep 1, 1990·Prostaglandins·G HonstraW Uedelhoven
Aug 18, 2000·Free Radical Biology & Medicine·M K Cathcart, V A Folcik
Apr 1, 2010·Therapeutic Advances in Endocrinology and Metabolism·Venkat VangavetiR Lee Kennedy
May 29, 1987·Biochemical and Biophysical Research Communications·K V HonnB F Sloane
Dec 1, 1988·Hypertension·R J GryglewskiJ R Vane
Apr 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·N AugéS Parthasarathy
Dec 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T C SimonJ M Bailey

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