PMID: 11312811Apr 21, 2001Paper

Inhibition of radical reaction of apolipoprotein B-100 and alpha-tocopherol in human plasma by green tea catechins

Journal of Agricultural and Food Chemistry
R HashimotoS Kojo

Abstract

(-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg), (-)-epigallocatechin gallate (EGCg), and Trolox inhibited the decreases of apolipoprotein B-100 (apoB) and alpha-tocopherol in a radical reaction of human plasma initiated by Cu(2+). The concentrations of EC, EGC, ECg, EGCg, and Trolox for 50% inhibition (IC50) of apoB fragmentation were 39.1, 42.2, 14.6, 21.3, and 36.2 microM, respectively. Similar IC50 values were observed for alpha-tocopherol consumption, indicating the close relationship between apoB fragmentation and alpha-tocopherol consumption. These results demonstrate that tea catechins serve as an effective antioxidant in plasma and that the gallate group has a strong antioxidative activity.

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Citations

Nov 13, 2008·Archives of Toxicology·Chung S YangShengmin Sang
May 15, 2003·Archives of Biochemistry and Biophysics·Ann E HagermanMichael J Davies
Dec 17, 2005·Antioxidants & Redox Signaling·Shengmin SangChung S Yang
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Chung S YangXiaofeng Meng
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Susana CoimbraAlice Santos-Silva
Jul 8, 2015·Journal of Traditional and Complementary Medicine·Hsin-Hung LinJhih-Ying Ciou
Jan 18, 2006·Molecular Nutrition & Food Research·Yung-Hsi KaoChia-Lin Chen
May 7, 2008·Biomedical Materials·Dong-Wook HanHan-Ki Park
Sep 14, 2007·International Journal of Food Sciences and Nutrition·N WatanabeH Aoki
May 6, 2004·Bioorganic & Medicinal Chemistry Letters·Tae-Sook JeongWoo Song Lee
Oct 30, 2003·Journal of Agricultural and Food Chemistry·Christine Counet, Sonia Collin

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