PMID: 16527005Mar 11, 2006Paper

Inhibition of RANKL as a treatment for osteoporosis: preclinical and early clinical studies

Current Osteoporosis Reports
Michael McClung

Abstract

Osteoporosis and several other bone disorders occur when there is an imbalance between the resorption and formation components of bone remodeling activity. Therapies available for some of these conditions modulate the activity of osteoclasts and/or osteoblasts. The recent discoveries of receptor activator of NF-kappaB ligand (RANKL), an endogenous activator of osteoclastogenenesis and osteoclast activity and its inhibitor, osteoprotegerin (OPG) as pivotal regulatory factors in the pathogenesis of bone diseases like osteoporosis provide unique targets for therapeutic agents. In laboratory animals and now in humans, administering forms of OPG markedly inhibits osteoclast activity and improves bone strength, documenting that the strategy of inhibiting RANKL activity has therapeutic promise. A highly specific, fully human antibody against RANKL has been produced (denosumab) that in early studies in humans reduces bone turnover and improves bone density. Attributes of denosumab in these clinical studies include a very rapid onset of action, sustained effects for several months after a single injection, and good tolerability. These results provide the basis for studies evaluating the effectiveness of denosumab in several clinical con...Continue Reading

References

Nov 1, 1988·Endocrinology·N TakahashiT Suda
Aug 1, 1986·The Journal of Clinical Investigation·G C NicholsonT J Martin
May 8, 1997·Biochemical and Biophysical Research Communications·E TsudaK Higashio
Nov 14, 1997·Nature Medicine·V IotsovaR Bravo
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S MoronyC R Dunstan
Apr 25, 2000·Bone·T A BatemanS J Simske
Aug 10, 2000·The American Journal of Pathology·D L LaceyA J Polverino
Aug 22, 2000·The Journal of Pathology·T J Chambers
Sep 1, 2000·Science·S L Teitelbaum
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·UNKNOWN American Society for Bone and Mineral Research President's Committee on Nomenclature
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R K FuchsC M Snow
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J BekkerC R Dunstan
Mar 10, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·B BolonJ Z Sheng
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael P Whyte, Anne E Hughes
Jul 19, 2002·The New England Journal of Medicine·Michael P WhyteSteven Mumm
Oct 9, 2002·The American Journal of Pathology·Evan RomasMatthew T Gillespie
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Teresa L Johnson-PaisRobin J Leach
Apr 12, 2003·Journal of Cellular Biochemistry·Rachel M LocklinB Lawrence Riggs
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Volker ViereckLorenz C Hofbauer
Jan 1, 1965·Journal of Dental Research·B N EPKER, H M FROST
Sep 23, 2003·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·John C ClohisyYousef Abu-Amer
Dec 13, 2003·Clinical & Experimental Metastasis·Tomoko OkadaMasato Kodaka
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John C HuangRobert A Nissenson
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pirow J BekkerAlex M DePaoli

❮ Previous
Next ❯

Citations

Apr 21, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H M ZhuS J Zhao
Sep 19, 2007·Breast Cancer Research and Treatment·David Cella, Lesley J Fallowfield
Dec 30, 2009·International Urology and Nephrology·Csaba AmbrusIstvan Mucsi
Mar 23, 2011·Current Osteoporosis Reports·Julie A Sterling, Scott A Guelcher
Jul 27, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Scott A Guelcher, Julie A Sterling
Jul 2, 2011·Rheumatology·Yu-Hsiang HsuMing-Shi Chang
Mar 22, 2007·Seminars in Dialysis·Rukshana C Shroff, Catherine M Shanahan
Mar 17, 2011·BMC Research Notes·Anne C Bay-JensenMorten A Karsdal
Dec 7, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A ScillitaniUNKNOWN ABC Group
Aug 14, 2009·Veterinary Surgery : VS·Andrea I SpahniMichael H Stoffel
May 12, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Anke Heidewig HautmannErnst Holler
Dec 15, 2010·Bone·Roland BaronR Graham G Russell
Feb 5, 2015·Journal of Materials Science. Materials in Medicine·Maria Grazia RaucciLuigi Ambrosio
Aug 8, 2015·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Hong-Du WangHua Jiang
Mar 6, 2007·Nature Clinical Practice. Rheumatology·Philipp DreesLars C Huber
Nov 20, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keiichi KoizumiIkuo Saiki
May 17, 2008·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Morten A KarsdalClaus Christiansen
Aug 4, 2010·Expert Opinion on Therapeutic Targets·Joel JulesXu Feng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.