Abstract
Environmental chemicals that alter steroid production could interfere with male reproductive development and function. Three agricultural antifungal triazoles that are known to modulate expression of cytochrome P450 (CYP) genes and enzymatic activities were tested for effects on steroidogenesis using rat in vivo (triadimefon), rat in vitro (myclobutanil and triadimefon), and human in vitro (myclobutanil, propiconazole, and triadimefon) model systems. Hormone production was measured in testis organ cultures from untreated adult and neonatal rats, following in vitro exposure to 1, 10, or 100 muM of myclobutanil or triadimefon. Myclobutanil and triadimefon reduced media levels of testosterone by 40-68% in the adult and neonatal testis culture, and altered steroid production in a manner that indicated CYP17-hydroxylase/17,20 lyase (CYP17A1) inhibition at the highest concentration tested. Rat to human comparison was explored using the H295R (human adrenal adenocarcinoma) cell line. Following 48 h exposure to myclobutanil, propiconazole, or triadimefon at 1, 3, 10, 30, or 100 muM, there was an overall decrease in estradiol, progesterone, and testosterone by all three triazoles. These data indicate that myclobutanil, propiconazole, an...Continue Reading
References
Jan 1, 1975·World Health Organization Technical Report Series
Aug 1, 1991·Clinical Endocrinology·D EngelhardtC Jaspers
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·W WoutersM Venet
Nov 1, 1987·Journal of Steroid Biochemistry·M Ayub, M J Levell
May 1, 1988·Antimicrobial Agents and Chemotherapy·D P HangerJ T Shaw
Apr 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K M CroftonL W Reiter
Feb 1, 1983·Biology of Reproduction·C WaeberT Lemarchand-Beraud
Apr 1, 1993·Endocrinology·A M HaavistoI Huhtaniemi
Aug 1, 1996·Toxicology and Applied Pharmacology·Q D Walker, R B Mailman
Oct 6, 1997·Reproductive Toxicology·L E GrayT Colborn
Apr 23, 1999·Critical Reviews in Toxicology·J C CookP M Foster
Oct 9, 1999·Clinical Microbiology Reviews·M A Ghannoum, L B Rice
Mar 9, 2002·Toxicology and Applied Pharmacology·Helle Raun AndersenEva Cecilie Bonefeld-Jørgensen
Mar 4, 2003·Environmental Health Perspectives·Jürg A ZarnJosef R Schlatter
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER
Mar 12, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·R ReevesD A Cory-Slechta
May 18, 2004·Brain Research·R ReevesD A Cory-Slechta
Jun 10, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Klara HilscherovaJohn P Giesy
Jul 16, 2004·Archives of Environmental Contamination and Toxicology·T OkuboI Kano
Nov 24, 2004·Endocrine Research·Eva R TröskenWerner K Lutz
Apr 29, 2006·Toxicology and Applied Pharmacology·Douglas B TullyDavid J Dix
Oct 5, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Amber K GoetzDavid J Dix
Mar 27, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew T MartinDavid J Dix
Sep 6, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Camilla TaxvigAnne Marie Vinggaard
Oct 25, 2007·Analytical and Bioanalytical Chemistry·Markus Hecker, John P Giesy
Dec 11, 2007·International Journal of Andrology·C TaxvigC Nellemann
May 5, 2009·Toxicology and Applied Pharmacology·Amber K Goetz, David J Dix
Citations
May 28, 2013·Archives of Toxicology·Wiebke PrutnerPablo Steinberg
Jan 24, 2013·Environmental Science and Pollution Research International·Damien BaudiffierFrançois Brion
Mar 3, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sanne A B HermsenAldert H Piersma
Sep 19, 2014·International Journal of Environmental Research and Public Health·Svenja RiekePhilip Marx-Stoelting
Feb 19, 2013·Toxicology and Applied Pharmacology·Maarke J E RoelofsMajorie B M van Duursen
Mar 12, 2013·Environmental Toxicology and Pharmacology·Minling GaoJing Guo
Jun 6, 2012·Reproductive Toxicology·Sanne A B HermsenAldert H Piersma
May 9, 2012·Toxicology·Damien BaudiffierFrançois Brion
Sep 4, 2014·Archives of Toxicology·T HeiseP Marx-Stoelting
Feb 17, 2015·Toxicology and Applied Pharmacology·Mandana GhisariEva Cecilie Bonefeld-Jørgensen
Jun 28, 2016·Critical Reviews in Toxicology·Katie Paul FriedmanRichard C Peffer
Nov 20, 2016·Integrated Environmental Assessment and Management·Joanne L ParrottJames R Wheeler
Apr 5, 2017·International Journal of Molecular Sciences·Javiera F De la PazMiguel L Allende
Jun 22, 2017·Pharmacology·Shuyan CaoRen-Shan Ge
Dec 8, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Derik E HaggardKatie Paul Friedman
Apr 10, 2010·Systems Biology in Reproductive Medicine·Michael P Diamond
Oct 6, 2020·Frontiers in Pharmacology·Zackary MontoyaSang-Hyuck Park
Jun 9, 2018·Bulletin of Environmental Contamination and Toxicology·Mariana Machado-NevesMariella B Freitas
Apr 23, 2017·Ecotoxicology·Xiaocui DongChonggang Wang
Nov 18, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Caroline Lucia PintoPatience Browne
Apr 1, 2021·Environmental Pollution·Shuchun WuMingrong Qian
Apr 27, 2021·Basic & Clinical Pharmacology & Toxicology·Ivan Ortega-BlakeLourdes Rodríguez-Fragoso
Aug 18, 2020·Ecotoxicology and Environmental Safety·Yosra Ben OthmèneChristophe Lemaire