PMID: 7544196May 1, 1995Paper

Inhibition of rat colon contractility by prostacyclin (IP-) receptor agonists: involvement of NANC neurotransmission

British Journal of Pharmacology
Y M Qian, R L Jones

Abstract

1. The possibility that prostacyclin (IP-) receptor agonists inhibit spontaneous contractions of the rat isolated colon by activating enteric neurones has been investigated. Cicaprost was used as the test agonist because of its high stability, selectivity and potency (IC50 = 3.8 nM). 2. The Na+ channel blockers saxitoxin (STX, 1 nM) and tetrodotoxin (TTX, 1 microM), whilst having little effect on resting spontaneous activity, virtually abolished the inhibitory actions of cicaprost (10 nM) and nicotine (3 microM); inhibitory responses to isoprenaline (20 nM) were not affected. Phentolamine (1 microM), propranolol (1 microM) and atropine (1 microM) had no effect on cicaprost inhibition. These data are compatible with release of inhibitory NANC transmitter(s) by cicaprost. 3. A transmitter role for nitric oxide was investigated. The nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine methyl ester (L-NAME, 100 microM) inhibited the actions of both cicaprost (10 nM) and nicotine (3 microM) by 50-60%, but did not affect responses to isoprenaline (20 nM) or sodium nitroprusside (1-5 microM). The enantiomeric D-NAME (100 microM), which has negligible NOS inhibitory activity, had no effect on the action of cicaprost. 4. The i...Continue Reading

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Citations

May 24, 1995·European Journal of Pharmacology·H WiseR L Jones
Nov 22, 1997·European Journal of Pharmacology·L BörjessonD S Delbro
Jan 1, 1996·Pharmacology & Therapeutics·R A Armstrong
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Jan 9, 2009·Journal of Pharmacological Sciences·Ikuo MurakamiToshihiko Murayama
Jul 28, 2010·The Journal of Pharmacology and Experimental Therapeutics·Keith MorrisonMartine Clozel
Apr 1, 1997·Journal of Cardiovascular Pharmacology·R L JonesJ K Ho
Feb 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Van Crombruggen, R A Lefebvre
Feb 23, 2021·ERJ Open Research·Richard W ChapmanWalter Perkins

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